N^G-Nitro-L-arginine methyl Ester Potentiates the Effect of Aminophylline on the Isolated Rat Hemidiaphragm
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概要
- 論文の詳細を見る
The effects of different concentrations of NG-nitro-<sc>L</sc>-arginine methyl ester (<sc>L</sc>-NAME) (0.3, 1, 3, and 10 mM), a non-selective inhibitor of NOS, on the effect of aminophylline on the isometric contraction of the isolated rat hemidiaphragm were investigated. The muscle contractions were induced by direct subtetanic electrical stimulation. Aminophylline (0.36 – 3.60 mM) produced a typical concentration-dependent increase in both parameters of the isometric contraction: tension developed (Td) and the maximum rate of rise of tension (dT/dt max). The second series of additions of aminophylline produced a more pronounced effect. <sc>L</sc>-NAME (0.3, 1, 3, and 10 mM, 30 min of incubation without stimulation) itself did not change Td and dT/dt max. However, <sc>L</sc>-NAME (1, 3, and 10 mM) produced a statistically significant potentiation of the effect of aminophylline on Td and dT/dt max.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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Stojanovic Radan
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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Todorovic Zoran
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Stojanovic Radan
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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PROSTRAN Milica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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NESIC Zorica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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VUCKOVIC Sonja
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine University of B
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Prostran Milica
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Vuckovic Sonja
セルビア・モンテネグロ
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Vuckovic Sonja
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Nesic Zorica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Todorovic Zoran
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Nesic Zorica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Stojanovic Radan
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Prostran Milica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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