N^G-Nitro-L-arginine Methyl Ester-Induced Potentiaton of the Effect of Aminophylline on Rat Diaphragm : the Role of Extracellular Calcium
スポンサーリンク
概要
- 論文の詳細を見る
The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 – 3.60 mM) was investigated. In a Ca2+-free medium, N G-nitro-<sc>L</sc>-arginine methyl ester (<sc>L</sc>-NAME) (1 and 3 mM) depressed tension developed (Td) and also aminophylline-induced potentiation of Td in a concentration-dependent manner. Verapamil (2.5 μM) or nicardipine (20 μM) significantly antagonized the potentiating effect of <sc>L</sc>-NAME on Td in a calcium-containing medium. However, in the presence of verapamil or nicardipine, <sc>L</sc>-NAME still produced statistically significant potentiation of the cumulative concentrations of aminophylline (0.36 – 3.60 mM), given in the second series.
- 社団法人 日本薬理学会の論文
- 2004-12-01
著者
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Stojanovic Radan
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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Todorovic Zoran
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Stojanovic Radan
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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PROSTRAN Milica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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NESIC Zorica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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CEROVAC-COSIC Natasa
Clinic for Child Neurology and Psychiatry, Medical Faculty, University of Belgrade
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VUCKOVIC Sonja
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine University of B
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CEROVAC-COSIC Natasa
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of B
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Prostran Milica
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Vuckovic Sonja
セルビア・モンテネグロ
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Vuckovic Sonja
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Nesic Zorica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Cerovac-cosic Natasa
Clinic For Child Neurology And Psychiatry Medical Faculty University Of Belgrade
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Todorovic Zoran
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Nesic Zorica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Stojanovic Radan
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Prostran Milica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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