Higher Environmental Temperature Potentiates Cataleptic Effect of Fentanyl in Rats
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概要
- 論文の詳細を見る
The influence of higher environmental temperature (HET=30±1°C) on fentanyl-induced behavior was studied in unrestrained rats. Subacute exposure (3 days) of rats to HET significantly (P<0.01) increased the cataleptic effect of fentanyl citrate (0.5 mg/kg), in comparison to the corresponding exposure to normal environmental temperature (NET=22±1°C). Also, the hyperthermic response of rats to a low dose of fentanyl citrate (0.2 - 0.5 mg/kg) was significantly (P<0.01) potentiated, and the hypothermic response to a high dose of fentanyl citrate (1.5 mg/kg) was significantly (P<0.05) attenuated after exposure to HET. Fentanyl-induced hyperexcitability, loss of righting reflex, loss of corneal reflex and analgesia were not significantly affected by HET. This study provides the first evidence on the influence of environmental temperature on drug-induced catalepsy. HET-induced potentiation of the cataleptic response to fentanyl could be the result of an interference with behavioral thermoregulation.
- 社団法人 日本薬理学会の論文
- 1998-12-01
著者
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Todorovic Zoran
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Ivanovic Milovan
Faculty Of Chemistry University Of Belgrade
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PROSTRAN Milica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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VUCKOVIC Sonja
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine University of B
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RISTOVIC Zorana
Institute of Oncology and Radiology
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MICOVIC Ivan
Faculty of Chemistry, University of Belgrade
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BELES Dusan
linDepartment of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, University
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Beles Dusan
Lindepartment Of Clinical Pharmacology Pharmacology And Toxicology School Of Medicine University Of
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Prostran Milica
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Vuckovic Sonja
セルビア・モンテネグロ
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Vuckovic Sonja
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Todorovic Zoran
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Prostran Milica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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