Aminophylline Pretreatment Modulates the Nitric Oxide System of the Isolated Rat Diaphragm : the Role of Frequency of the Electrical Stimulation

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The effect of different frequencies of direct subtetanic electrical stimulation (14, 20, and 30 Hz) and aminophylline (AMPh) pretreatment on the effect of NG-nitro-<sc>L</sc>-arginine methyl ester (<sc>L</sc>-NAME) (1 mM) on isolated rat diaphragm was investigated. <sc>L</sc>-NAME potentiated tension developed (Td) in the diaphragm pretreated with a single concentration of AMPh (1.08 mM) in a frequency-dependent manner. The effect was significantly different in comparison with muscle incubated 30 min with Tyrode solution only. In the muscle pretreated with cumulative concentrations of AMPh (0.36 - 3.60 mM), the frequency-dependent potentiation of Td induced by <sc>L</sc>-NAME and the difference between <sc>L</sc>-NAME-treated and untreated muscle were lost.
社団法人日本薬理学会の論文
2005-09-20