Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat : a New Target for Carbamazepine?
スポンサーリンク
概要
- 論文の詳細を見る
This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 – 1000 nmol/paw) coadministrated with a pro-inflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 – 1000 nmol/paw), a nonselective adenosine-receptor antagonist, as well as DPCPX (10 – 30 nmol/paw), a selective adenosine A1-receptor antagonist, with carbamazepine, significantly depressed its anti-hyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A1 receptors.
- 社団法人 日本薬理学会の論文
- 2006-04-20
著者
-
Boskovic Bogdan
Medical Military Academy
-
Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
-
Vuckovic Sonja
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
-
TOMIC Maja
Department of Pharmacology, Faculty of Pharmacy, University of Belgrade
-
STEPANOVIC-PETROVIC Radica
Department of Pharmacology, Faculty of Pharmacy, University of Belgrade
-
UGRESIC Nenad
Department of Pharmacology, Faculty of Pharmacy, University of Belgrade
-
Tomic Maja
Department Of Pharmacology Faculty Of Pharmacy University Of Belgrade
-
Ugresic Nenad
Department Of Pharmacology Faculty Of Pharmacy University Of Belgrade
-
Stepanovic-petrovic Radica
Department Of Pharmacology Faculty Of Pharmacy University Of Belgrade
-
Prostran Milica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
関連論文
- Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury : It Is Never Too Late for the Pretreatment
- Thienopyridine Resistance Among Patients Undergoing Intracoronary Stent Implantation and Treated With Dual Antiplatelet Therapy : Assessment of Some Modifying Factors
- Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat
- Type of Electrical Stimulation Influences Diaphragm Response to Adrenoceptor and Calcium Channel Modulators : the Role of Extracellular and Intracellular Calcium Events
- Aminophylline Pretreatment Modulates the Nitric Oxide System of the Isolated Rat Diaphragm : the Role of Frequency of the Electrical Stimulation
- N^G-Nitro-L-arginine Methyl Ester-Induced Potentiaton of the Effect of Aminophylline on Rat Diaphragm : the Role of Extracellular Calcium
- N^G-Nitro-L-arginine methyl Ester Potentiates the Effect of Aminophylline on the Isolated Rat Hemidiaphragm
- Higher Environmental Temperature Potentiates Cataleptic Effect of Fentanyl in Rats
- Abrupt Cessation of One-Year Clopidogrel Treatment Is Not Associated With Thrombotic Events
- Antinociceptive Activity of the Novel Fentanyl Analogue iso-Carfentanil in Rats
- Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat : a New Target for Carbamazepine?
- Abrupt Cessation of One-Year Clopidogrel Treatment Is Not Associated With Thrombotic Events