Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

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The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.
社団法人日本薬理学会の論文
2006-12-20

著者

Stojanovic Radan
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
Todorovic Zoran
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
Basta-jovanovic Gordana
Department Of Pathology School Of Medicine University Of Belgrade
Chatterjee Prabal
School Of Pharmacy & Biomolecular Sciences University Of Brighton
Stojanovic Radan
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
PROSTRAN Milica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
NESIC Zorica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
RADOJEVIC-SKODRIC Sanja
Department of Pathology, School of Medicine, University of Belgrade
THIEMERMANN Christoph
The William Harvey Research Institute, St. Bartholomew's and Royal London School of Medicine and Den
VELICKOVIC Ruzica
Institute of Mental Health, Laboratory of Biochemistry
Prostran Milica
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
Nesic Zorica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
Thiemermann Christoph
The William Harvey Research Institute St. Bartholomew's And Royal London School Of Medicine And
Radojevic-skodric Sanja
Department Of Pathology School Of Medicine University Of Belgrade
Velickovic Ruzica
Institute Of Mental Health Laboratory Of Biochemistry
Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
Todorovic Zoran
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
Nesic Zorica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
Stojanovic Radan
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
Prostran Milica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade

Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

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