Acute Protective Effects of Simvastatin in the Rat Model of Renal Ischemia-Reperfusion Injury : It Is Never Too Late for the Pretreatment
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概要
- 論文の詳細を見る
Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and reperfusion were similar regarding total histological score. However, simvastatin injected 30 min before ischemia was 30% – 75% more effective in reduction of serum creatinine levels and interstitial edema score, while its injections 5 and 30 min before reperfusion were 25% – 60% more effective in reduction of tubular necrosis score and fractional excretion of Na+. However, the observed differences do not seem to offer significant advantage in clinical settings.
- 2008-08-20
著者
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Stojanovic Radan
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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Todorovic Zoran
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Basta-jovanovic Gordana
Department Of Pathology School Of Medicine University Of Belgrade
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Chatterjee Prabal
School Of Pharmacy & Biomolecular Sciences University Of Brighton
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Stojanovic Radan
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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PROSTRAN Milica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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NESIC Zorica
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of
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RADOJEVIC-SKODRIC Sanja
Department of Pathology, School of Medicine, University of Belgrade
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VELICKOVIC Ruzca
Institute of Mental Health, Laboratory of Biochemistry
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THIEMERMANN Christoph
The William Harvey Research Institute, St. Bartholomew's and Royal London School of Medicine and Den
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VELICKOVIC Ruzica
Institute of Mental Health, Laboratory of Biochemistry
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Prostran Milica
Inst. For Pharmacology Clinical Pharmacology And Toxiciology Fac. Of Medicine Univ. Of Belgrade Serb
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Prostran Milica
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Nesic Zorica
Department Of Pharmacology Clinical Pharmacology And Toxicology School Of Medicine University Of Bel
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Thiemermann Christoph
The William Harvey Research Institute St. Bartholomew's And Royal London School Of Medicine And
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Radojevic-skodric Sanja
Department Of Pathology School Of Medicine University Of Belgrade
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Velickovic Ruzica
Institute Of Mental Health Laboratory Of Biochemistry
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Todorovic Zoran
Department Of Pharmacology Clinical Pharmacology And Toxicology Faculty Of Medicine University Of Be
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Todorovic Zoran
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Nesic Zorica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Stojanovic Radan
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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Prostran Milica
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine University of Belgrade
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