Losartan Preserves Integrity of Cardiac Gap Junctions and PGC-1 .ALPHA. Gene Expression and Prevents Cellular Apoptosis in Remote Area of Left Ventricular Myocardium Following Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
This study tests the hypothesis that peroxisome proliferator activated receptor-iγ /i coactivator 1iα/i (PGC-1iα/i) and the integrity of gap junctions (GJs) were suppressed and the number of apoptotic bodies was increased in remote viable areas of left ventricle following acute myocardial infarction (AMI), which can be reversed by losartan therapy. Open chest surgery was consecutively performed on 32 adult male Sprague-Dawley rats. These rats were classified into 4 groups (in/i = 8/each group): group I, AMI (by ligation of left coronary artery (LCA) without treatment); group II, AMI with losartan 20 mg/kg/day; group III, sham control (without LAD ligation); and group IV, sham control with losartan 20 mg/kg/day. Echocardiography was performed on day 1 prior to AMI and on day 14 just before the rats were to be sacrificed for cellular and molecular studies. The results showed that mRNA expression of PGC-1iα/i, integrated area (iμ/imsup2/sup) of clustered connexin43 (Cx43) spots, and Cx43 GJs were substantially down-regulated and the number of apoptotic bodies was markedly increased in nontreated AMI rats compared with healthy control and losartan-treated AMI rats on day 14 following AMI (all values of iP/i 0.001). Additionally, day14 left ventricular (LV) ejection fraction was significantly lower in nontreated AMI rats than in healthy control and losartan-treated AMI rats (all values of iP/i 0.0001).br Down-regulation of GJs and PGC-1iα/i gene expression and cellular death were frequently observed in remote viable areas of LV following AMI. Losartan therapy reversed the adverse effects of AMI and preserved LV function. br
著者
-
Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medici
-
Youssef Ali
Cardiology Department Suez Canal University Hospital
-
Chang Li-teh
Basic Science Nursing Department Meiho Institute Of Technology
-
Wu Chiung-jen
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Chua Sarah
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Yip Hon-kan
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Sheu Jiunn-Jye
Medical Center, Chang Gung University College of Medicine
-
Wang Chi-Young
Department of Life Science, National Pingtung University of Science and Technology
-
Yip Hon-Kan
Division of Cardiology, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
-
Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
-
Chang Li-Teh
Basic Science, Nursing Department, Meiho Institute of Technology, Pingtung, Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung
-
Wu Chiung-Jen
Division of Cardiology, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
関連論文
- Safety and Efficacy of Transradial vs Transfemoral Arterial Primary Coronary Angioplasty for Acute Myocardial Infarction : Single-Center Experience
- Can a Penetration Catheter (Tornus) Substitute Traditional Rotational Atherectomy for Recanalizing Chronic Total Occlusions?
- Bilateral Percutaneous Ulnar Artery Approach for Retrograde Chronic Total Occlusion Intervention
- Utilization of a Double-Wire Technique to Treat Long Extended Spiral Dissection of the Right Coronary Artery : Evaluation of Incidence and Mechanisms
- Cobalt Chromium Coronary Stents and Drug-Eluting Stents in Real Practice
- Impact of PercuSurge GuardWire Device on Prevention and Reduction of Recovery Time From Complete Heart Block in Patients With Acute Inferior Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Platelet Activation in Patients With Chronic Nonvalvular Atrial Fibrillation
- No Age-Related Change in Circulating Endothelial Progenitor Cells in Healthy Subjects
- Bilateral Cardiac Catheterizations : The Safety and Feasibility of a Superficial Forearm Venous and Transradial Arterial Approach
- Levels and Values of Inflammatory Markers in Patients With Angina Pectoris
- The Safety and Feasibility of Transradial Cutting Balloon Angioplasty : Immediate results, benefits, and limitations
- The Feasibility and Safety of Early Discharge for Low Risk Patients with Acute Myocardial Infarction after Successful Direct Percutaneous Coronary Intervention
- Comparison of Primary Angioplasty and Conservative Treatment on Short- and Long-term Outcome in Octogenarian or Older Patients with Acute Myocardial Infarction
- Association Between Circulating Level of CD40 Ligand and Angiographic Morphologic Features Indicating High-Burden Thrombus Formation in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Impact of Hyperglycemic Control on Left Ventricular Myocardium : A Molecular and Cellular Basic Study in a Diabetic Rat Model
- Successful Transradial Antegrade Coronary Intervention of a Rare Right Coronary Artery High Anterior Downward Takeoff Anomalous Chronic Total Occlusion by Double-Anchoring Technique and Retrograde Guidance
- Role of Stromal Cell-Derived Factor-1α, Level and Value of Circulating Interleukin-10 and Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Level and Prognostic Value of Serum Myeloperoxidase in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Long-Term Outcomes of Intervention for Unprotected Left Main Coronary Artery Stenosis : Coronary Stenting vs Coronary Artery Bypass Grafting
- Clinical Presentation and Prognostic Factors of Patients With Acute ST-Segment Elevation Myocardial Infarction Following Emergent Revascularization for Left Main Coronary Artery Obstruction
- Autologous Bone Marrow-Derived Mononuclear Cell Therapy Prevents the Damage of Viable Myocardium and Improves Rat Heart Function Following Acute Anterior Myocardial Infarction
- Cilostazol Therapy Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat Model
- Shock Wave Therapy Applied to Rat Bone Marrow-Derived Mononuclear Cells Enhances Formation of Cells Stained Positive for CD31 and Vascular Endothelial Growth Factor
- Cytotoxic T Lymphocyte Antigen 4 Gene Polymorphism Associated With ST-Segment Elevation Acute Myocardial Infarction
- Association of Interleukin-10 Level With Increased 30-Day Mortality in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Feasibility and Safety of Transradial Stenting for Unprotected Left Main Coronary Artery Stenoses
- Level and Value of Interleukin-18 in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Impact of PercuSurge Device Conjugative With Intracoronary Administration of Nitroprusside on No-Reflow Phenomenon Following Primary Percutaneous Coronary Intervention
- Strong Correlation Between Serum Levels of Inflammatory Mediators and Their Distribution in Infarct-Related Coronary Artery
- Angiographic and Clinical Outcome in ST-Segment Elevation Myocardial Infarction Patients Receiving an Adjunctive Double Bolus Regimen of Tirofiban for Primary Percutaneous Coronary Intervention(CLINICAL INVESTIGATION)
- Platelet Activity is a Biomarker of Cardiac Necrosis and Predictive of Untoward Clinical Outcomes in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Stenting
- Propylthiouracil Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats
- Primary Percutaneous Coronary Intervention Lowers the Incidence of Ischemic Mitral Regurgitation in Patients With Acute ST-Elevated Myocardial Infarction
- Transradial Approach Percutaneous Coronary Interventions in an Out-Patient Clinic : Safety and Feasibility Trial of Same-Day Discharge Versus Hospital Admission
- Prognostic Value of R-Wave Voltage in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Benefit of Revascularization in Non-Infarct-Related Artery in Multivessel Disease Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Time Course of Platelet Activation and von Willebrand Factor in Patients With Non-Valvular Atrial Fibrillation After Ischemic Stroke : Evaluation of Prognostic Determinants
- Level and Value of Interleukin-18 After Acute Ischemic Stroke
- Time Course and Prognostic Value of Plasma Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients After Ischemic Stroke
- The Safety and Feasibility of Bilateral Radial Approach in Chronic Total Occlusion Percutaneous Coronary Intervention
- Value and Level of Plasma Homocysteine in Patients With Angina Pectoris Undergoing Coronary Angiographic Study
- Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model
- The Prognostic Value of Atrial Fibrillation on 30-Day Clinical Outcome in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Comparison of Losartan and Carvedilol on Attenuating Inflammatory and Oxidative Response and Preserving Energy Transcription Factors and Left Ventricular Function in Dilated Cardiomyopathy Rats
- Seasonal Distribution of Pacemaker Implantation for Symptomatic Bradycardia
- Outcome of Patients With Profound Cardiogenic Shock After Cardiopulmonary Resuscitation and Prompt Extracorporeal Membrane Oxygenation Support : A Single-Center Observational Study
- Prognostic Value of Activated Toll-Like Receptor-4 in Monocytes Following Acute Myocardial Infarction
- Losartan Preserves Integrity of Cardiac Gap Junctions and PGC-1 .ALPHA. Gene Expression and Prevents Cellular Apoptosis in Remote Area of Left Ventricular Myocardium Following Acute Myocardial Infarction
- Impact of Diabetes on Cardiomyocyte Apoptosis and Connexin43 Gap Junction Integrity Role of Pharmacological Modulation : bRole of Pharmacological Modulation/b
- The Utilization of a Commercial Soil Nucleic Acid Extraction Kit and PCR for the Detection of Clostridium tetanus and Clostridium chauvoei on Farms after Flooding in Taiwan
- Effect of Adjunctive Tirofiban Therapy on Angiographic and Clinical Outcomes in Patients With ST-segment Elevated Acute Myocardial Infarction Undergoing Primary Stenting
- Re-Elevation of High-Sensitivity C-Reactive Protein but not the von Willebrand Factor After Withdrawing Atorvastatin Therapy in Patients With Unstable Angina Undergoing Coronary Artery Stenting A Kinetic Study:A Kinetic Study
- Impact of Elevated Plasma Total Homocysteine Concentration on Coronary Atherosclerosis in Chinese Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Downregulation of Peroxisme Proliferator Activated Receptor Gamma Co-Activator 1.ALPHA. in Diabetic Rats Role of Pharmacomodulation:Role of Pharmacomodulation
- Prognostic Factors and Outcomes in Young Chinese Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Value and level of circulating endothelial progenitor cells, angiogenesis factors and mononuclear cell apoptosis in patients with chronic kidney disease