Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model
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概要
- 論文の詳細を見る
This study investigated six-month angiographic results of autologous bone marrow mononuclear cell (BMMNC) transplantation immediately following acute myocardial in-farction (AMI) in a mini-pig model.AMI was induced by left anterior descending artery ligation. Twenty-four mini-pigs were equally divided into group 1 [AMI plus saline injection in infarcted area (IA)], group 2 (AMI plus BMMNC transplantation into non-IA), group 3 (AMI plus BMMNC implantation into IA), and group 4 (sham control). One-week cultured BMMNCs (3.0 × 107) were immediately transplanted following AMI induction. Angiographic studies over 6 months demonstrated that mitral regurgitation (MR) was lower in groups 3 and 4 than in groups 1 and 2 (all P < 0.01). Wall motion scores and left ventricular ejection fraction (LVEF) were higher in groups 3 and 4 than in groups 1 and 2 (all P < 0.05). Collateral circulation was higher in group 3 than in groups 1 and 2 ( P < 0.01). The wall thickness of the IA was higher, whereas the heart weight was lower in group 3 than in groups 1 and 2 (all P < 0.01).Immediate autologous BMMNC transplantation into IA is superior to saline-treated only or BMMNC transplantation into non-IA following AMI for reducing MR and improving LVEF.
著者
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Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medici
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Chiang Chiang-Hua
Department of Veterinary Medicine, National Pingtung University of Science and Technology
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Yip Hon-Kan
Department of Cardiology, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung
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Wu Chiung-Jen
Departments of Cardiology, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gun
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Chang Li-teh
Basic Science Nursing Department Meiho Institute Of Technology
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Pei Sung-nan
Department Of Hematology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University
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Ko Sheung-fat
Department Of Radiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University
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Sheu Jiunn-jye
Department Of Cardiovascular Surgery Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gun
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Yuen Chun-Man
Department of Neurosurgery
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YEN Chia-Hung
Department of Life Science, National Pingtung University of Science and Technology
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Pei Sung-Nan
Department of Hematology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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Chua Sarah
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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Bhasin Anuj
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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Yip Hon-Kan
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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Wu Chiung-Jen
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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Yuen Chun-Man
Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
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