Cytotoxic T Lymphocyte Antigen 4 Gene Polymorphism Associated With ST-Segment Elevation Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Background Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production. The purpose of the present study was to determine the frequency distribution of an A/G single nucleotide polymorphism at position 49 in exon 1 of the CTLA-4 gene, which may be a functional related-genetic risk marker for the development of ST-segment elevation (ST-se) acute myocardial infarction (AMI). Methods and Results A total of 503 consecutive patients, consisting of 250 ST-se AMI patients undergoing primary coronary angioplasty (group 1), 203 angina pectoris patients undergoing elective coronary angioplasty (group 2) and 50 patients with chest pain and normal coronary angiographic findings (group 3), were enrolled in the present study. The frequency of the G/G genotype was significantly higher in group 1 (53.2%) than in groups 2 (33.0%) and 3 (36.0%) (p=0.0005). In group 1, patients with a G/G genotype had significantly higher levels of high-sensitivity C-reactive protein and white blood cell counts, and much higher incidences of multi-vessel disease, greater lesion lengths, advanced congestive heart failure (≥ class 3) and 30-day mortality, than patients with G/A or A/A genotypes (p values<0.05 in all cases). Multivariate analysis of the enrolled baseline variables (age, gender, diabetes mellitus, smoking, hypertension and hypercholesterolemia) and the genotypes (G/G, A/G and A/A) demonstrated that G/G genotype is the only independent predictor of development of AMI (p<0.0001). Conclusion The G/G genotype polymorphism of the CTLA-4 gene is associated with increased risk of AMI.
- 社団法人日本循環器学会の論文
- 2007-07-20
著者
-
YOUSSEF Ali
Cardiology Department, Suez Canal University Hospital
-
Wu Chiung-jen
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Wu Chiung-jen
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University College Of Medicine
-
Chang Li-Teh
Basic Science, Nursing Department, Meiho Institute of Techology
-
Yip Hon-Kan
Chang Gung University College of Medicine
-
Lee Fan-yen
Division Of Cardiovascular Surgery Department Of Surgery Chang Gung Memorial Hospital-kaohsiung Medi
-
Yip Hon-kan
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Youssef Ali
Cardiology Department Suez Canal University Hospital
-
Yip Hon-Kan
Department of Cardiology, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung
-
Wang Pei-wen
Internal Medicine, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung Univer
-
Sheu Jiunn-Jye
Cardiovascular Surgery, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung U
-
Lee Fan-Yen
Cardiovascular Surgery, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gung U
-
Wu Chiung-Jen
Departments of Cardiology, Chang Gung Memorial Hospital Hospital-Kaohsiung Medical Center, Chang Gun
-
Chang Li-teh
Basic Science Nursing Department Meiho Institute Of Technology
-
Sheu Jiunn-jye
Division Of Cardiology Department Of Cardiovascular Surgery Chang Gung Memorial Hospital-kaohsiung M
-
Yip Hon-kan
Division Of Cardiology Department Of Neurology Chang Gung Memorial Hospital-kaohsiung Medical Center
-
Wang Pei-wen
Internal Medicine Chang Gung Memorial Hospital Hospital-kaohsiung Medical Center Chang Gung Universi
-
Wu Chiung-Jen
Department of Cardiology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
関連論文
- Safety and Efficacy of Transradial vs Transfemoral Arterial Primary Coronary Angioplasty for Acute Myocardial Infarction : Single-Center Experience
- Cobalt Chromium Coronary Stents and Drug-Eluting Stents in Real Practice
- Impact of PercuSurge GuardWire Device on Prevention and Reduction of Recovery Time From Complete Heart Block in Patients With Acute Inferior Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Platelet Activation in Patients With Chronic Nonvalvular Atrial Fibrillation
- Comparison of Drug-Eluting Stent With Bare Metal Stent for Distal De Novo Unprotected Left Main Coronary Artery Stenosis : – A Propensity Score-Matched Cohort Study –
- Association Between Circulating Level of CD40 Ligand and Angiographic Morphologic Features Indicating High-Burden Thrombus Formation in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Impact of Hyperglycemic Control on Left Ventricular Myocardium : A Molecular and Cellular Basic Study in a Diabetic Rat Model
- Role of Stromal Cell-Derived Factor-1α, Level and Value of Circulating Interleukin-10 and Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Level and Prognostic Value of Serum Myeloperoxidase in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Long-Term Outcomes of Intervention for Unprotected Left Main Coronary Artery Stenosis : Coronary Stenting vs Coronary Artery Bypass Grafting
- Clinical Presentation and Prognostic Factors of Patients With Acute ST-Segment Elevation Myocardial Infarction Following Emergent Revascularization for Left Main Coronary Artery Obstruction
- Autologous Bone Marrow-Derived Mononuclear Cell Therapy Prevents the Damage of Viable Myocardium and Improves Rat Heart Function Following Acute Anterior Myocardial Infarction
- Cilostazol Therapy Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat Model
- Shock Wave Therapy Applied to Rat Bone Marrow-Derived Mononuclear Cells Enhances Formation of Cells Stained Positive for CD31 and Vascular Endothelial Growth Factor
- Cytotoxic T Lymphocyte Antigen 4 Gene Polymorphism Associated With ST-Segment Elevation Acute Myocardial Infarction
- Prognostic Predictors of Sinus Rhythm Control by Amiodarone and Electrical Cardioversion in Patients Undergoing Percutaneous Transluminal Mitral Valvuloplasty for Rheumatic Atrial Fibrillation
- Association of Interleukin-10 Level With Increased 30-Day Mortality in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Feasibility and Safety of Transradial Stenting for Unprotected Left Main Coronary Artery Stenoses
- Level and Value of Interleukin-18 in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Impact of PercuSurge Device Conjugative With Intracoronary Administration of Nitroprusside on No-Reflow Phenomenon Following Primary Percutaneous Coronary Intervention
- Strong Correlation Between Serum Levels of Inflammatory Mediators and Their Distribution in Infarct-Related Coronary Artery
- Angiographic and Clinical Outcome in ST-Segment Elevation Myocardial Infarction Patients Receiving an Adjunctive Double Bolus Regimen of Tirofiban for Primary Percutaneous Coronary Intervention(CLINICAL INVESTIGATION)
- Platelet Activity is a Biomarker of Cardiac Necrosis and Predictive of Untoward Clinical Outcomes in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Stenting
- Coronary interventions in Asian-Pacific Countries
- Propylthiouracil Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats
- Primary Percutaneous Coronary Intervention Lowers the Incidence of Ischemic Mitral Regurgitation in Patients With Acute ST-Elevated Myocardial Infarction
- Time Course of Platelet Activation and von Willebrand Factor in Patients With Non-Valvular Atrial Fibrillation After Ischemic Stroke : Evaluation of Prognostic Determinants
- Level and Value of Interleukin-18 After Acute Ischemic Stroke
- Time Course and Prognostic Value of Plasma Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients After Ischemic Stroke
- Popliteal Artery Occlusion in a Young Baseball Athlete
- Comparison of Drug-Eluting Stent With Bare Metal Stent for Distal De Novo Unprotected Left Main Coronary Artery Stenosis : A Propensity Score-Matched Cohort Study
- Six-Year Clinical Follow-up After Treatment of Diffuse In-Stent Restenosis With Cutting Balloon Angioplasty Followed by Intracoronary Brachytherapy With Liquid Rhenium-188-Filled Balloon via Transradial Approach
- Value and Level of Plasma Homocysteine in Patients With Angina Pectoris Undergoing Coronary Angiographic Study
- Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model
- Comparison of Losartan and Carvedilol on Attenuating Inflammatory and Oxidative Response and Preserving Energy Transcription Factors and Left Ventricular Function in Dilated Cardiomyopathy Rats
- Outcome of Patients With Profound Cardiogenic Shock After Cardiopulmonary Resuscitation and Prompt Extracorporeal Membrane Oxygenation Support : A Single-Center Observational Study
- Prognostic Value of Activated Toll-Like Receptor-4 in Monocytes Following Acute Myocardial Infarction
- Losartan Preserves Integrity of Cardiac Gap Junctions and PGC-1 .ALPHA. Gene Expression and Prevents Cellular Apoptosis in Remote Area of Left Ventricular Myocardium Following Acute Myocardial Infarction
- Impact of Diabetes on Cardiomyocyte Apoptosis and Connexin43 Gap Junction Integrity Role of Pharmacological Modulation : bRole of Pharmacological Modulation/b
- Re-Elevation of High-Sensitivity C-Reactive Protein but not the von Willebrand Factor After Withdrawing Atorvastatin Therapy in Patients With Unstable Angina Undergoing Coronary Artery Stenting A Kinetic Study:A Kinetic Study
- Downregulation of Peroxisme Proliferator Activated Receptor Gamma Co-Activator 1.ALPHA. in Diabetic Rats Role of Pharmacomodulation:Role of Pharmacomodulation