Angiographic and Clinical Outcome in ST-Segment Elevation Myocardial Infarction Patients Receiving an Adjunctive Double Bolus Regimen of Tirofiban for Primary Percutaneous Coronary Intervention(CLINICAL INVESTIGATION)
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概要
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Background Because of different dosages, the efficacy of adjunctive tirofiban therapy for primary percutaneous coronary intervention (PCI) is currently unclear. The hypothesis that a double bolus regimen of tirofiban will improve angiographic and clinical outcomes in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing PCI was tested in the present study. Methods and Results Primary PCI was performed in 217 STEMI patients: 80 received standard PCI (control group) and 137 received tirofiban (tirofiban group). Tirofiban was given as a bolus (10mg/kg) in the emergency room and again upon arrival at the cardiac catheterization laboratory, followed by infusion of 0.15mg・kg^<-1>・min^<-1> until the total dose reached 12.5mg. The primary endpoint was emergency target vessel revascularization, recurrent myocardial infarction, or cardiovascular mortality at 30 days and 1 year. Baseline clinical and angiographic variables of the 2 groups were similar, as were angiographic results after PCI and bleeding complications at 30 days. The primary 30-day and 1-year endpoints were 5.1% and 11.7% in the tirofiban group, respectively, vs 10.0% (p=0.171) and 18.8% (p=0.151) in the control group. Conclusion Although angiographic and clinical benefits were not demonstrated, the results suggest that research into an effective and uniform dosing regimen of adjunctive tirofiban therapy for PCI is warranted.
- 社団法人日本循環器学会の論文
- 2006-04-20
著者
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YIP Hon-Kan
Division of Cardiology, Department of Internal Medicine
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CHEN Shyh-Ming
Division of Cardiology, Department of Internal Medicine
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HSIEH Yuan-Kai
Division of Cardiology, Department of Internal Medicine
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Wu Chiung-Jen
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medi
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Wu Chiung-jen
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Wu Chiung-jen
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University College Of Medicine
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Fu Morgan
Division of Cardiology, Chang Gung Memorial Hospital, Kaohsiung
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Fu Morgan
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Hsieh Yuan-Kai
Chang Gung University College of Medicine
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Fang Chih-Yuan
Chang Gung University College of Medicine
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Chen Shyh-Ming
Chang Gung University College of Medicine
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Yip Hon-Kan
Chang Gung University College of Medicine
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Fu Morgan
Chang Gung University College of Medicine
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Hsieh Yuan-kai
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Yip Hon-kan
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Fang Chih-yuan
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Guo Gary
Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital
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Fang Chi-Yan
Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital
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Yip Hon-kan
Division Of Cardiology Department Of Neurology Chang Gung Memorial Hospital-kaohsiung Medical Center
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Guo Gary
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gang University College Of Medicine
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Guo Gary
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University College Of Medicine
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Guo Gary
Division Of Cardiology Department Of Internal Medicine Kaohsiung Chang Gung Memorial Hospital
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Fu Morgan
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
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Wu Chiung-jen
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
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Chen Shyh-ming
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
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Yip Hon-kan
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
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