Time Course and Prognostic Value of Plasma Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients After Ischemic Stroke
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概要
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Background The association between plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and prognostic outcomes in patients after ischemic stroke remains unknown. The present study tested the hypothesis that NT-proBNP level is noticeably increased after ischemic stroke and that elevated NT-proBNP is associated with unfavorable clinical outcomes (UFCO). Methods and Results Blood samples for NT-proBNP levels were collected serially and examined with sandwich immunoassay after acute ischemic stroke in 86 consecutive patients. The NT-proBNP levels were also measured in 30 healthy control volunteers and 30 at-risk control subjects. The NT-proBNP levels were significantly higher at 4 intervals after ischemic stroke than in healthy and at-risk control subjects (all p<0.001). The NT-proBNP decreased to a significantly lower level on day 21 and to a substantially lower level on day 90. Additionally, the NT-proBNP level at any of the 4 intervals was significantly higher in patients with than in patients without UFCO (defined as combined congestive heart failure〓class 3, acute myocardial infarction, recurrent stroke or any cause of death) (all p<0.01). Multivariate analysis demonstrated that age and NIH Stroke Scale were the 2 strongest independent predictors of increased NT-proBNP levels (all p<0.01). Furthermore, increased NT-proBNP (〓150pg/ml) was the strongest independent predictor of long-term (mean follow-up: 24 months) UFCO (26 patients) (all p<0.05). Conclusions The NT-proBNP level was markedly elevated after acute ischemic stroke and declined substantially thereafter. An increased NT-proBNP level was strongly and independently correlated with UFCO in patients after ischemic stroke.
- 社団法人日本循環器学会の論文
- 2006-03-20
著者
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YIP Hon-Kan
Division of Cardiology, Department of Internal Medicine
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SUN Cheuk-Kwan
Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical C
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Chen Mien-Cheng
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medi
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Yip Hon-Kan
Chang Gung University College of Medicine
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Chen Mien-Cheng
Chang Gung University College of Medicine
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Sun Cheuk-kwan
Division Of Neurosurgery General Surgery Chang Gung Memorial Hospital-kaohsiung Medical Center Chang
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Chen Mien-cheng
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
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Chang Li-teh
Basic Science Nursing Department Meiho Institute Of Technology
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Liou Chia-wei
Division Of Cardiology Department Of Neurology Chang Gung Memorial Hospital-kaohsiung Medical Center
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Liou Chia-wei
Department Of Neurology Chang Gung Memorial Hospital
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Chang Li-Teh
Meiho Institute of Technology
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Yip Hon-kan
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
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Liou Chia-wei
Department Of Neurology
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Sun Cheuk-kwan
Division Of General Surgery Department Of Surgery Kaohsiung Chang Gung Memorial Hospital And Chang Gung University College Of Medicine
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