Strong Correlation Between Serum Levels of Inflammatory Mediators and Their Distribution in Infarct-Related Coronary Artery
スポンサーリンク
概要
- 論文の詳細を見る
Background Little is known regarding the correlation between circulating levels of inflammatory mediators and their distribution within the infarct-related coronary artery (ICA). Methods and Results Atherothrombotic tissue and blood were aspirated by export suction catheter from the ICA in 49 patients with an acute myocardial infarction (AMI)<6h duration who underwent primary percutaneous coronary intervention (PCI). Blood samples were collected before PCI for levels of high-sensitivity (hs) C-reactive protein (CRP), soluble P-selectin (sP-selectin) and white blood cell (WBC) counts. Immunohistochemical staining was performed for localization of CRP within the ICA. Staining intensity was graded for macrophage and extracellular tissue (0:no staining; 1+:<30%, 2+: 30% to 60%, and 3+:>60%). The hs-CRP levels were markedly higher in grade 3+ compared with both grade 2+ and grade 1+ of macrophage and extracellular staining of CRP (all p values <0.0001), and in grade 2+ compared with grade 1+ (p<0.001). Additionally, the ICA had a significantly higher sP-selectin level and WBC count compared with the systemic circulation (p<0.0001). Furthermore, the ICA level of sP-selectin was noticeably higher in patients with a total atherothrombus volume <0.5cm^3 than in patients with total volume <0.5cm^3 (p<0.0001). Moreover, correlation analysis demonstrated that the increase in the ICA level of sP-selectin was significantly related to the increase in the WBC count in the artery (r=0.548, p<0.0001). Multiple analysis identified an increased circulating level of hs-CRP as the only independent predictor of ≥2+ in macrophage (p<0.0001) and ≥2+ in extracellular (p<0.0001) staining of CRP. Conclusions Following AMI, the sP-selectin level and WBC count were markedly higher in the ICA than in the circulation. Moreover, the circulating level of hs-CRP was strongly associated with ICA localization of CRP.
- 社団法人日本循環器学会の論文
- 2006-06-20
著者
-
YIP Hon-Kan
Division of Cardiology, Department of Internal Medicine
-
CHANG Li-Teh
Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology
-
Wu Chiung-Jen
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medi
-
Wu Chiung-jen
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Wu Chiung-jen
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University College Of Medicine
-
Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medici
-
Yip Hon-kan
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Sun Cheuk-kwan
Division Of Neurosurgery General Surgery Chang Gung Memorial Hospital-kaohsiung Medical Center Chang
-
Chang Li-teh
Basic Science Nursing Department Meiho Institute Of Technology
-
Yip Hon-kan
Division Of Cardiology Department Of Neurology Chang Gung Memorial Hospital-kaohsiung Medical Center
-
Wu Chiung-jen
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Yip Hon-kan
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Yip Hon-Kan
Division of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
-
Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
-
Sun Cheuk-Kwan
Department of General Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine
関連論文
- Safety and Efficacy of Transradial vs Transfemoral Arterial Primary Coronary Angioplasty for Acute Myocardial Infarction : Single-Center Experience
- Can a Penetration Catheter (Tornus) Substitute Traditional Rotational Atherectomy for Recanalizing Chronic Total Occlusions?
- Bilateral Percutaneous Ulnar Artery Approach for Retrograde Chronic Total Occlusion Intervention
- Utilization of a Double-Wire Technique to Treat Long Extended Spiral Dissection of the Right Coronary Artery : Evaluation of Incidence and Mechanisms
- Cobalt Chromium Coronary Stents and Drug-Eluting Stents in Real Practice
- Impact of 6-Month Angiographic Restenosis Inside Bare-Metal Stents on Long-Term Clinical Outcome in Patients With Coronary Artery Disease
- Impact of PercuSurge GuardWire Device on Prevention and Reduction of Recovery Time From Complete Heart Block in Patients With Acute Inferior Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Platelet Activation in Patients With Chronic Nonvalvular Atrial Fibrillation
- No Age-Related Change in Circulating Endothelial Progenitor Cells in Healthy Subjects
- Bilateral Cardiac Catheterizations : The Safety and Feasibility of a Superficial Forearm Venous and Transradial Arterial Approach
- Levels and Values of Inflammatory Markers in Patients With Angina Pectoris
- The Safety and Feasibility of Transradial Cutting Balloon Angioplasty : Immediate results, benefits, and limitations
- The Feasibility and Safety of Early Discharge for Low Risk Patients with Acute Myocardial Infarction after Successful Direct Percutaneous Coronary Intervention
- Comparison of Primary Angioplasty and Conservative Treatment on Short- and Long-term Outcome in Octogenarian or Older Patients with Acute Myocardial Infarction
- Comparison of Drug-Eluting Stent With Bare Metal Stent for Distal De Novo Unprotected Left Main Coronary Artery Stenosis : – A Propensity Score-Matched Cohort Study –
- Association Between Circulating Level of CD40 Ligand and Angiographic Morphologic Features Indicating High-Burden Thrombus Formation in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Impact of Hyperglycemic Control on Left Ventricular Myocardium : A Molecular and Cellular Basic Study in a Diabetic Rat Model
- Successful Transradial Antegrade Coronary Intervention of a Rare Right Coronary Artery High Anterior Downward Takeoff Anomalous Chronic Total Occlusion by Double-Anchoring Technique and Retrograde Guidance
- Role of Stromal Cell-Derived Factor-1α, Level and Value of Circulating Interleukin-10 and Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Level and Prognostic Value of Serum Myeloperoxidase in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Long-Term Outcomes of Intervention for Unprotected Left Main Coronary Artery Stenosis : Coronary Stenting vs Coronary Artery Bypass Grafting
- Clinical Presentation and Prognostic Factors of Patients With Acute ST-Segment Elevation Myocardial Infarction Following Emergent Revascularization for Left Main Coronary Artery Obstruction
- Autologous Bone Marrow-Derived Mononuclear Cell Therapy Prevents the Damage of Viable Myocardium and Improves Rat Heart Function Following Acute Anterior Myocardial Infarction
- Cilostazol Therapy Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat Model
- Shock Wave Therapy Applied to Rat Bone Marrow-Derived Mononuclear Cells Enhances Formation of Cells Stained Positive for CD31 and Vascular Endothelial Growth Factor
- Cytotoxic T Lymphocyte Antigen 4 Gene Polymorphism Associated With ST-Segment Elevation Acute Myocardial Infarction
- Prognostic Predictors of Sinus Rhythm Control by Amiodarone and Electrical Cardioversion in Patients Undergoing Percutaneous Transluminal Mitral Valvuloplasty for Rheumatic Atrial Fibrillation
- Association of Interleukin-10 Level With Increased 30-Day Mortality in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Feasibility and Safety of Transradial Stenting for Unprotected Left Main Coronary Artery Stenoses
- Level and Value of Interleukin-18 in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Impact of PercuSurge Device Conjugative With Intracoronary Administration of Nitroprusside on No-Reflow Phenomenon Following Primary Percutaneous Coronary Intervention
- Strong Correlation Between Serum Levels of Inflammatory Mediators and Their Distribution in Infarct-Related Coronary Artery
- Angiographic and Clinical Outcome in ST-Segment Elevation Myocardial Infarction Patients Receiving an Adjunctive Double Bolus Regimen of Tirofiban for Primary Percutaneous Coronary Intervention(CLINICAL INVESTIGATION)
- Platelet Activity is a Biomarker of Cardiac Necrosis and Predictive of Untoward Clinical Outcomes in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Stenting
- Coronary interventions in Asian-Pacific Countries
- Propylthiouracil Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats
- Primary Percutaneous Coronary Intervention Lowers the Incidence of Ischemic Mitral Regurgitation in Patients With Acute ST-Elevated Myocardial Infarction
- Transradial Approach Percutaneous Coronary Interventions in an Out-Patient Clinic : Safety and Feasibility Trial of Same-Day Discharge Versus Hospital Admission
- Prognostic Value of R-Wave Voltage in Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Benefit of Revascularization in Non-Infarct-Related Artery in Multivessel Disease Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Time Course of Platelet Activation and von Willebrand Factor in Patients With Non-Valvular Atrial Fibrillation After Ischemic Stroke : Evaluation of Prognostic Determinants
- Level and Value of Interleukin-18 After Acute Ischemic Stroke
- Time Course and Prognostic Value of Plasma Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients After Ischemic Stroke
- Popliteal Artery Occlusion in a Young Baseball Athlete
- Comparison of Drug-Eluting Stent With Bare Metal Stent for Distal De Novo Unprotected Left Main Coronary Artery Stenosis : A Propensity Score-Matched Cohort Study
- The Safety and Feasibility of Bilateral Radial Approach in Chronic Total Occlusion Percutaneous Coronary Intervention
- Six-Year Clinical Follow-up After Treatment of Diffuse In-Stent Restenosis With Cutting Balloon Angioplasty Followed by Intracoronary Brachytherapy With Liquid Rhenium-188-Filled Balloon via Transradial Approach
- Value and Level of Plasma Homocysteine in Patients With Angina Pectoris Undergoing Coronary Angiographic Study
- Six-Month Angiographic Study of Immediate Autologous Bone Marrow Mononuclear Cell Implantation on Acute Anterior Wall Myocardial Infarction Using a Mini-Pig Model
- The Prognostic Value of Atrial Fibrillation on 30-Day Clinical Outcome in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Comparison of Losartan and Carvedilol on Attenuating Inflammatory and Oxidative Response and Preserving Energy Transcription Factors and Left Ventricular Function in Dilated Cardiomyopathy Rats
- Seasonal Distribution of Pacemaker Implantation for Symptomatic Bradycardia
- Outcome of Patients With Profound Cardiogenic Shock After Cardiopulmonary Resuscitation and Prompt Extracorporeal Membrane Oxygenation Support : A Single-Center Observational Study
- Prognostic Value of Activated Toll-Like Receptor-4 in Monocytes Following Acute Myocardial Infarction
- Losartan Preserves Integrity of Cardiac Gap Junctions and PGC-1 .ALPHA. Gene Expression and Prevents Cellular Apoptosis in Remote Area of Left Ventricular Myocardium Following Acute Myocardial Infarction
- Impact of Diabetes on Cardiomyocyte Apoptosis and Connexin43 Gap Junction Integrity Role of Pharmacological Modulation : bRole of Pharmacological Modulation/b
- Effect of Adjunctive Tirofiban Therapy on Angiographic and Clinical Outcomes in Patients With ST-segment Elevated Acute Myocardial Infarction Undergoing Primary Stenting
- Re-Elevation of High-Sensitivity C-Reactive Protein but not the von Willebrand Factor After Withdrawing Atorvastatin Therapy in Patients With Unstable Angina Undergoing Coronary Artery Stenting A Kinetic Study:A Kinetic Study
- Impact of Elevated Plasma Total Homocysteine Concentration on Coronary Atherosclerosis in Chinese Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
- Downregulation of Peroxisme Proliferator Activated Receptor Gamma Co-Activator 1.ALPHA. in Diabetic Rats Role of Pharmacomodulation:Role of Pharmacomodulation
- Prognostic Factors and Outcomes in Young Chinese Patients With Acute Myocardial Infarction Undergoing Primary Coronary Angioplasty
- Value and level of circulating endothelial progenitor cells, angiogenesis factors and mononuclear cell apoptosis in patients with chronic kidney disease