Association Between Circulating Level of CD40 Ligand and Angiographic Morphologic Features Indicating High-Burden Thrombus Formation in Patients With Acute Myocardial Infarction Undergoing Primary Coronary Intervention
スポンサーリンク
概要
- 論文の詳細を見る
Background This study tested the hypothesis that in the acute phase of myocardial infarction (MI), the circulating level of soluble CD40 ligand (sCD40L), an index of platelet activation, is predictive of angiographic morphologic features that indicate high-burden thrombus formation (HBTF) in the infarct-related artery (IRA). Methods and Results This prospective study included 162 consecutive patients : 64 with HBTF and 98 with low-burden thrombus formation (LBTF). All patients had a Killip's classification ≤3 ST-segment elevation acute myocardial infarction (AMI) of onset <12h who were undergoing primary percutaneous coronary intervention (PCI). Blood samples for measurement of the circulating levels of sCD4L and high-sensitivity C-reactive protein (hs-CRP) and white blood cell (WBC) count were collected before PCI. The circulating levels of sCD40L and hs-CRP, and the WBC count were also evaluated in 20 normal control subjects. Blood was aspirated by export suction catheter from the intracoronary artery (ICA) in 49 HBTF patients. The WBC count, and the circulating levels of hs-CRP and sCD40L were significantly higher in the HBTF and LBTF groups than in the normal control subjects (all p<0.005). Additionally, the circulating levels of sCD40L and the WBC count were substantially higher in the HBTF than in the LBTF patients (all p<0.001). Furthermore, in HBTF patients the ICA had a significantly higher sCD40L level and WBC count compared with the values for the systemic circulation (all p<0.001). Multiple statistical analyses identified increased circulating level of sCD40L as the most independent predictor of HBTF in the IRA (p<0.0001). Conclusions The sCD40L level is the most independent predictor of angiographic morphologic features that indicate HBTF in the acute phase of MI.
- 2007-11-20
著者
-
YIP Hon-Kan
Division of Cardiology, Department of Internal Medicine
-
YOUSSEF Ali
Cardiology Department, Suez Canal University Hospital
-
YANG Cheng-Hsu
Division of Cardiology, Department of Internal Medicine
-
CHANG Li-Teh
Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology
-
Wu Chiung-Jen
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medi
-
Wu Chiung-jen
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Wu Chiung-jen
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University College Of Medicine
-
Chua Sarah
Division of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
-
Yeh Kuo-Ho
Division of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine
-
Yang Cheng-Hsu
Chang Gung University College of Medicine
-
Yip Hon-Kan
Chang Gung University College of Medicine
-
Lee Fan-yen
Division Of Cardiovascular Surgery Department Of Surgery Chang Gung Memorial Hospital-kaohsiung Medi
-
Chua Sarah
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital
-
Yeh Kuo-ho
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital
-
Yip Hon-kan
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Youssef Ali
Cardiology Department Suez Canal University Hospital
-
Sheu Jiunn-Jye
Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang G
-
Yang Cheng-hsu
Division Of Cardiology Department Of Internal Medicine Chang Gung Memorial Hospital-kaohsiung Medica
-
Yang Cheng-hsu
Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University College Of Medicine
-
Lee Fan-Yen
Department of Cardiovascular Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang G
-
Chang Li-teh
Basic Science Nursing Department Meiho Institute Of Technology
-
Sheu Jiunn-jye
Division Of Cardiology Department Of Cardiovascular Surgery Chang Gung Memorial Hospital-kaohsiung M
-
Yip Hon-kan
Division Of Cardiology Department Of Neurology Chang Gung Memorial Hospital-kaohsiung Medical Center
-
Wu Chiung-jen
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Sheu Jiunn-jye
Department Of Cardiovascular Surgery Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gun
-
Yang Cheng-hsu
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Chua Sarah
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Yip Hon-kan
Division Of Cardiology Chang Gung Memorial Hospital-kaohsiung Medical Center Chang Gung University C
-
Lee Fan-Yen
Department of Cardiovascular Surgery, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine
関連論文
- Safety and Efficacy of Transradial vs Transfemoral Arterial Primary Coronary Angioplasty for Acute Myocardial Infarction : Single-Center Experience
- Can a Penetration Catheter (Tornus) Substitute Traditional Rotational Atherectomy for Recanalizing Chronic Total Occlusions?
- Bilateral Percutaneous Ulnar Artery Approach for Retrograde Chronic Total Occlusion Intervention
- Utilization of a Double-Wire Technique to Treat Long Extended Spiral Dissection of the Right Coronary Artery : Evaluation of Incidence and Mechanisms
- Cobalt Chromium Coronary Stents and Drug-Eluting Stents in Real Practice
- Impact of 6-Month Angiographic Restenosis Inside Bare-Metal Stents on Long-Term Clinical Outcome in Patients With Coronary Artery Disease
- Impact of PercuSurge GuardWire Device on Prevention and Reduction of Recovery Time From Complete Heart Block in Patients With Acute Inferior Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Platelet Activation in Patients With Chronic Nonvalvular Atrial Fibrillation
- No Age-Related Change in Circulating Endothelial Progenitor Cells in Healthy Subjects
- Bilateral Cardiac Catheterizations : The Safety and Feasibility of a Superficial Forearm Venous and Transradial Arterial Approach