No Age-Related Change in Circulating Endothelial Progenitor Cells in Healthy Subjects

概要

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Endothelial progenitor cells were isolated from peripheral blood obtained from 32 healthy volunteers without cardiovascular risk factors who ranged in age from 20 to 61 years (mean [± SD] age, 34.1 ± 9.6 years). The fractions of CD34+ endothelial progenitor cells expressing kinase insert domain receptor-1, CD62E, or CD31 were analyzed with flow cytometry. Correlation analysis demonstrated that there was no significant correlation between subject age and the fraction of circulating CD34+ mononuclear cells expressing kinase insert domain receptor-1 (P = 0.324; r = −0.180). Similarly, there was no significant correlation between subject age and the fraction of circulating CD34+ mononuclear cells expressing CD62E (P = 0.496; r = −0.125) or the fraction of circulating CD34+ mononuclear cells expressing CD31 (P = 0.245; r = −0.212). In conclusion, the experimental results showed that there was no age-related change in the basal level of circulating endothelial progenitor cells in healthy subjects without cardiovascular risk factors.
インターナショナル・ハート・ジャーナル刊行会の論文