Short-Term Feeding of Fish Oil Down-Regulates the Expression of Pyruvate Dehydrogenase E1 Alpha Subunit mRNA in Mouse Brain

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概要

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• Previous studies have suggested that docosahexaenoic acid (DHA), contained in fish oil, prevents brain disease. In the current study, the effect of fish oil feeding on gene expression in the brain was investigated by suppression subtractive hybridization. We found that pyruvate dehydrogenase E1 alpha (PDHE1α) mRNA expression is down-regulated by fish oil feeding. We examined whether the expression of PDHE1α mRNA is altered by DHA treatment in differentiated PC12 cells. PDHE1α mRNA was reduced by supplementation of DHA with a significant decrease in cellular ATP level. These results indicate that fish oil feeding might modulate energy metabolism in the brain.

• 2005-02-23

著者

• Kato Norihisa

  Department Of Physics Faculty Of Science Kyushu University

• Kato Norihisa

  Department Of Applied Biochemistry Faculty Of Applied Biological Science Hiroshima University

• Kato Norihisa

  Department Of Molecular And Applied Bioscience Graduate School Of Biosphere Science Hiroshima Univer

• EZAKI Osamu

  Division of Clinical Nutrition, The National Institute of Health and Nutrition

• Ezaki Osamu

  Division Of Clinical Nutrition National Institute Of Health And Nutrition

• Tsuboyama Kasaoka

  Division Of Clinical Nutrition National Institute Of Health And Nutrition

• NOGUSA Yoshihito

  Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima Un

• YANAKA Noriyuki

  Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima Un

• SUMIYOSHI Naoki

  Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima Un

• KASEDA Yurika

  Department of Bioresource Science and Technology, Graduate School of Biosphere Science, Hiroshima Un

• Nogusa Yoshihito

  Department Of Molecular And Applied Bioscience Graduate School Of Biosphere Science Hiroshima Univer

• Sumiyoshi Naoki

  Department Of Molecular And Applied Bioscience Graduate School Of Biosphere Science Hiroshima Univer

• Kaseda Yurika

  Department Of Bioresource Science And Technology Graduate School Of Biosphere Science Hiroshima Univ

• Kaseda Yurika

  Department Of Molecular And Applied Bioscience Graduate School Of Biosphere Science Hiroshima Univer

• KATO Norihisa

  Department of Agricultural Chemistry, Nagoya University

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