Elevated Body Fat in Rats by the Dietary Nitric Oxide Synthase Inhibitor, L-N^ω Nitroarginine

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The influence of the dietary nitric oxide (NO) synthase inhibitor, L-N^ω nitroarginine (L-NNA) on body fat was examined in rats. In experiment 1,all rats were fed with the same amount of diet with or without 0.02% L-NNA for 8 wk. L-NNA intake caused elevations in serum triglyceride and body fat, and reduction in serum nitrate (a metabolite of nitric oxide). The activity of hepatic carnitine palmitoyl-transferase was reduced by L-NNA. In experiment 2,rats were fed for 8 wk with the same amount of diets with or without 0.02% L-NNA supplemented or not with 4% L-arginine. The elevation in body fat, and the reductions in serum nitrate and in the activity of hepatic carnitine palmitoyltransfererase by L-NNA were all suppressed by supplemental L-arginine. The results suggest that lower NO generation elevated not only serum triglyceride, but also body fat by reduced fatty acid oxidation.
社団法人日本農芸化学会の論文
1999-04-23