Synthesis and Mutagenic Activity of Alkyl Derivatives of 2-Amino-9H-pyrido[2, 3-b]indole
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概要
- 論文の詳細を見る
Two mutagenic compounds were isolated from the pyrolysate of soybean globulin: 2-amino-3-methyl-9H-pyrido[2, 3-b]indole (MeAC) and 2-amino-3-ethyl-9H-pyrido[2, 3-b]indole (EtAC). These two and other 3-substituted derivatives were synthesized by the condensation of 2-aminoindole with enaminonitriles, and tested for their mutagenic activity. The bulkiness of the alkyl group at C-3 position adjacent to the amino group was related to the mutagenic strength. 2-Amino-3-butyl-9H-pyrido[2, 3-b]indole and the bulkier alkyl derivatives were not mutagenic.
- 社団法人 日本農芸化学会の論文
著者
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Yoshida Daisuke
Central Research Institute Japan Tobacco Inc.
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Matsumoto Takashi
Central Research Institute Japan Tobacco Inc.
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TOMITA Hideo
Central Research Institute, The Japan Tobacco & Salt Public Corporation
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