[原著］上咽頭癌の放射線治療成績 : 特に再発様式と生存率について

概要

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From January 1985 to May 1991, 17 patients with carcinoma of the nasopharynx were treated with irradiation with or without induction chemotherapy. The UICC staging system (1987) was applied: 5 patients were I+II, 3 were stage III and 9 were stage IV. Induction chemotherapy was given to 12 patients who did not have any medical problems. Recurrence rate for the patients who achieved complete response at the initial treatment was 46.7% (7/15). T stage did not influence the incidence of local recurrence and distant metastases. We recognized the tendency for N stage to influence the incidence of distant metastases. No local recurrence was observed in patients who recieved over 71Gy. The 5-year recurrence free survial for all 17 patients were 46.1%, 75.0% for stage I + II, 66.7% for stage III and 33.3% for stage IV. The recurrence at the primary site and distant sites was more frequent in the combined-treatment group (45.5% and 36.4%), compared with the irradiation-alone group (25.5% and 25.0%). The 5-year recurrence free survival rate for combined treatment group and irradiation-alone group were 34.9% and 66.7%,respectively. These results suggest that induction chemotherapy is not beneficial in the treatment of carcinoma of the nasopharynx. However,prospective randomized trial is required to clearly evaluate the role of induction chemotherapy in the management of carcinoma of the nasopharynx.
琉球医学会,Ryukyu Medical Associationの論文