尿失禁に対する塩酸プロピベリンの臨床効果 : 尿失禁の病態分類別効果の検討

概要

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1日平均1回以上の尿失禁を自覚する患者86名に塩酸プロピベリン1日20mgを投与し,尿失禁の病態分類別にその臨床効果と安全性を検討した. 1)尿意切迫感,夜の排尿回数において切迫性尿失禁に有意に高い改善率が得られた. 2)昼の排尿回数では切迫性尿失禁に対する改善傾向がみられた. 3)自・他覚症状の総合改善度は全体で88.6%と高く,切迫感と腹圧性の両群に有意差はなかった. 4)副作用は14例に発現し,又,本剤に起因する臨床検査値異常が1例に認められたPropiverine hydrochloride was given to patients with subjective symptoms of urinary incontinence and its effect was evaluated in relation to the pathogenesis of incontinence. High improvement rates were obtained in patients with stress incontinence as well as those with urge incontinence. There was no significant difference between the two patient groups in the degree of improvement of subjective symptoms or objective findings. Under the present circumstances, where urinary incontinence is often treated by medical doctors other than urologists, this drug may be useful for the treatment of urinary incontinence since it would produce high therapeutic effects irrespective of the pathogenesis of incontinence.