残存髄膜腫の増大様式と腫瘍容積倍加時間の解析

概要

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The purpose of the present study was to determine the growth pattern and growth rate of residual meningiomas. We investigated the tumor volume doubling time (Td) based on serial MRIs and the tumor proliferative potential by the MIB-1 staining index in 17 residual meningiomas. During a follow-up period ranging from 2 to 120 months, there were seven rapid-growing meningiomas with a Td of 14.3±9.6 months, six slow-growing tumors with a Td of 81.3±14.3 months, and four shrinking tumors. The majority of the growing tumors increased in size constantly in an exponential fashion,except for 2 small slow-growing tumors which showed a fluctuating growth pattern.There was a significant correlation between the MIB-1 index and Td with a correlation coefficient of －0.54.We conclude that repeated observations of residual meningiomas with MRI and MIB-1 staining index are important for the prediction of future tumor growth.
信州医学会の論文