ペロスピロン投与後に知覚変容の改善及びめざめ現象が認められた統合失調症の１症例

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発症から約7年経過した統合失調症の幻覚妄想状態に対してペロスピロンを投与した後, 投薬内容が単剤化できたことに加え, 知覚変容の軽快及びめざめ現象が認められた症例を経験した｡患者は当科外来通院していたが, 幻聴･妄想に基づく問題行動が著しくなり当科に入院した｡幻聴, 自己の身体に関する知覚変容とそれらに付随した易怒性, 興奮が目立った｡ペロスピロン投与約2週間で上記症状はほぼ消失した｡それまでの思考･行動への後悔･反省, 疾患の気づきが認められた｡それに伴い, 現実に直面したことによる不安･焦燥が一過性に出現した。ペロスピロン投与による身体的な副作用は認められなかった｡入院当初は易怒性, 興奮がみられたが, 鎮静作用を主とする薬剤からペロスピロンへ変更することで, 全人的な改善を得ることができた｡統合失調症患者への認知機能改善を目的とする薬剤選択はQOLの改善に資するものと考えられた｡ We herein report on the successful treatment of a schizophrenia case using perospirone. After perospirone administration, the patient's sensory distortion improved, but he also developed a remarkable improvement of his cognitive function also called "awakenings". Furthermore, the simultaneous administration of several drugs could be avoided by the introduction of perospirone to treat this patient. The case was a 30-year-old man who had previously been an outpatient. He was hospitalized after the recurrence of auditory hallucinations, delusions and problematical behavior. At admission to the hospital, he showed auditory hallucinations, delusions including sensory distortion, irritability and psychomotor excitement. Almost all symptoms of sensory distortion disappeared within about two weeks after the start of perospirone treatment. He reflected on his actions, and regretted his previous way of thinking and behavior in the past, and gradually became more aware of his illness. Due to his improved cognitive function, he temporarily developed anxiety and mild agitation because he was confronting reality. No other side effects due to the administration of perospirone could be observed. Although irritability and psychomotor excitement were observed at the start of his hospitalization, we found that a greater general improvement could be obtained due to the perospirone treatment in comparison to the previous medication regimen which mainly consisted of sedative antipsychotic drugs. The administration of antipsychotic drugs, such as perospirone, which improve the cognitive function is therefore considered to greatly improve the QOL of schizophrenic patients.
九州精神神経学会の論文
2004-12-15

ペロスピロン投与後に知覚変容の改善及びめざめ現象が認められた統合失調症の１症例

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