動脈硬化症と糖尿病 : 最近の知見(<特集>動脈硬化とアフェレシス)

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Diabetes has been implicated in the pathogenesis of atherosclerotic vascular diseases, including coronary artery disease and stroke. Hyperglycemia, hypertension and dyslipidemia as well as chronic kidney disease (CKD) are potential risk factors for these vascular diseases ; however, uncertainty remains regarding whether intensive blood glucose control reduces the incidence of cardiovascular disease. Target levels of blood pressure and selection of antihypertensive medications in diabetic patients are also still controversial. Recently, CKD has been recognized as a novel risk factor for vascular diseases. Both albuminuria and reduced glomerular filtration rate are associated with higher incidence of cardiovascular events ; however, whether these manifestations of CKD impact independently on incident CAD and stroke is unknown, especially in Japanese diabetic patients. In this review, these issues are discussed on the basis of recent clinical and epidemiological studies in patients with diabetes.
2013-02-28

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