マウスにおけるショ糖および蜂蜜の摂取が生体内グルタチオン動態に与える急性的影響について

概要

論文の詳細を見る
Glutathione (reduced glutathione: GSH) is thiol antioxidant which is synthesized in animal cells. GSH plays an important role in the antioxidant mechanisms. In this study, we examined acute effects of intake of sucrose or honey on glutathione status in several organs with a mouse model. ICR female mice were divided into three groups. Control group took only tap water ad libitim for 16 hours. Sucrose group took 12% sucrose solution and honey group took 12% honey solution. In honey group, amount of GSH in liver and kidney increased as compared with control group. Sucrose group tended to increase with liver and kidney GSH. In addition, GSH/GSSG ratio in liver and kidney were high levels in these groups. In sucrose group and honey group, plasma GSH level and GSH/GSSG ratio increased. On the other hand, in erythrocyte, amount of GSH was reduced and GSSG was increased by intake of sucrose or honey. Therefore, intakes of sugars may be effective as temporary defense against oxidative stress because intakes of sugars contributed to increase GSH level and/or GSH/GSSG ratio in a liver playing a key role of the GSH synthesis.
2011-08-01