T0201-3-6 円周方向引張負荷に伴うブタ胸大動脈壁内微視的変形挙動の観察([T0201-3]細胞の構造と流れにおけるマイクロ・ナノスケール解析(3))

概要

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The artery walls consist of structural components that have various mechanical properties: elastin, collagen and smooth muscle cells. Such variety may cause heterogeneous deformation of the components at a microscopic level when arterial tissue is subjected to macroscopic uniform stretch. To examine this hypothesis, we sliced 15-μm-thick specimens from porcine thoracic aorta with cryotome, and stretched them under a transmitted light microscope to observe their microscopic deformation caused by macroscopic stretch. Microscopic strain was found to be highly heterogeneous: stretch ratio in the elastic lamina (EL) and smooth muscle layer (SML) was 1.1-2.3 and 1.1-2.1, respectively, at circumferential stretch ratio of 1.5. Strain difference between an EL and a SML adjacent to each other could be as high as 6 times. These results suggest that the microscopic deformation in the artery wall is highly heterogeneous. Mechanical environment of the artery wall might not be so homogeneous at a cellular level.
一般社団法人日本機械学会の論文
2010-09-04