T0201-1-4 Caイオン応答伝播時におけるPKCαの局在の変化([T0201-1]細胞の構造と流れにおけるマイクロ・ナノスケール解析(1))

概要

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In the vessel homeostasis, calcium wave propagation takes a important role at the point of integration endothelial cells activity. Protein Kinase C α(PKCα) is major protein as modulator of many biological procedures in endothelial cells and translocates by intracellular calcium uptake. But it is not understood whether PKCα-translocation is propagated by calcium wave propagation. Then we triggered calcium wave propagation by using PKCα-tagged-GFP. As a result, to similar to past study, PKCα-translocation was observed in stimulated cell. We confirmed that PKCα-translocation in non-stimulated cell was observed at the same time as calcium uptake, and found that intracellular PKCa tended to be localized on the edge of the stimulated cell side.
一般社団法人日本機械学会の論文
2010-09-04