431 せん断応力影響下における内皮細胞細胞膜タンパクの挙動解析

概要

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Endothelial cells (ECs) that line the inner surface of blood vessels are continuously exposed to shear stress induced by blood flow in vivo. It has been thought that the ECs have the mechanism to sense shear stress. Membrane proteins such as a receptor are known to be involved in signal transduction. Thus we thought that there is a relationship between membrane proteins and signal transduction induced by shear stress, and we studied the effect of shear stress on the membrane proteins of the cultured ECs. We visualized the movement of membrane proteins by labeling albumin with fluorescent particles. Before shear stress loading, the particles moved randomly. On the other hand, after shear stress loading, the particles moved in the direction of the downstream region on the cell membrane, and accumulated at the edge of the ECs. The velocity of the movements increased with increasing shear stress.
一般社団法人日本機械学会の論文
2003-08-05