717 界面制御したHAp/PLLA複合材料の曲げ変形・破壊特性に及ぼす加水分解の影響(OS1-2 生分解性ポリ乳酸とポリ乳酸系複合材料の変形と破壊)

概要

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The composite made from hydroxyapatite (HAp) and poly (L-lactic acid) (PLLA) is a high-revel candidate for scaffold materials in bone tissue engineering. We made the HAp/PLLA composites which have comparable in bending strength to neat PLLA owing to the improvement in interface strength, resulting from the interfacial control via surface treatment of HAp particles. In this study, we evaluated the effect of the hydrolysis of PLLA on the flexural properties of interface-controlled HAp/PLLA by conducting the three point flexural tests of these materials after immersed in phosphate buffer solution (PBS, 37℃, pH7.4) up to 12 weeks. For comparison, we also carried out tests for neat PLLA and untreated HAp/PLLA. Bending modulus and strength of untreated HAp/PLLA deteriorated faster than those of interface-controlled HAp/PLLA. Finally, the deterioration mechanisms were discussed from the viewpoint of the change in interfacial microstructure. The observation of fracture surfaces indicated that the hydrolysis of PLLA at the interface was locally accelerated in untreated HAp/PLLA.
一般社団法人日本機械学会の論文
2007-10-24