737 FSM法を用いたケラトサイト葉状仮足内におけるアクチン骨格構造の運動観察(S08-3 細胞の構造とメカノバイオロジー(3),S08 細胞の構造とメカノバイオロジー)

概要

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Recent analysis techniques of Fluorescence Speckle Microscopy (FSM), and Particle Imaging Velocimetry (PIV)-incorporated Image Correlation have been utilized for quantitative characterization of cytoskeletal actin dynamics in the lamella region of crawling fragments from fish keratocyte as simplified locomotory systems. Our aim is to elucidate how mechanical factors regulate actin structure reorganization, and therefore cell motility, by carrying out a quantitative analysis of the mechanical state of cytoskeletal actin structure in the lamella region of crawling keratocyte fragments. We show that a net compressive strain exists in the lamella region and point out its role as a potential regulator of the reorganization process through the modulation of actin depolymerization. Our results highlight the importance of mechanical factors in the regulation of directional cell motility.
社団法人日本機械学会の論文
2006-09-15