534 一重鎖DNAの環状化過程における塩基長の影響(T10-3 マイクロ・ナノバイオテクノロジー(3):デバイス開発・医療応用を目指して,大会テーマセッション,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

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"Bottom up" is another possible approach to nanotechnology as well as the conventional "top down" approach. This approach requires special nano-structural elements with a size of nanometers and a property of self-assembly to an elaborate product. One strong candidate for the materials of such elements is single-stranded DNA (ssDNA), because this material possesses strict base-pair specificity and selectivity. In the course of fabrication of DNA nanostructures, circular single-stranded DNA (cssDNA) is often used as the intermediate form. The cssDNA is constructed by the simple Dolinnaya's method, which uses two of ssDNA, a body of the ring (Precursor) and a mediator that brings the DNA ends together (Template). Precursor was certainly circularized by Template and a ligating enzyme, and formed the monomeric cssDNA in a topoisomeric fashion, but multimeric cssDNA is also produced which was constructed from many precursors. The amount of monomeric cssDNA and multimeric cssDNA were altered by the length and sequence of the precursor and template.
社団法人日本機械学会の論文
2008-08-02