ワルファリン内服患者におけるINRに影響を及ぼす因子(神経内科学教室岩田誠教授退任記念特別号)

概要

論文の詳細を見る
Preventive effect of warfarin for the development of cardiogenic embolism is well established. However, variability in the required dose for each individual makes it difficult to prescribe adequate dose of warfarin because of the potential risk of hemorrhage. In the present study, we retrospectively evaluated relationship between the international normalized ratio (INR) and several patient-specific clinical factors such as gender, age, body weight, patient's medical status, risk factors for stroke, renal/liver function, and hemostatic markers. Eighty-six patients (55: men, 31: women, mean age of 68 years) anticoagulated with oral warfarin between April 2004 and March 2006 were entered in the study. Among patient-specific factors, we analysed factors influencing INR during warfarin therapy. Under warfarin treatment, three factors were associated with increased INR/mg ratio; body weight<40 kg, coagulopathy, and renal failure. In contrast, following factors decreased INR/mg ratio; age < 50 years, body weight ≥80 kg, and increased levels of platelet activation markers.
東京女子医科大学の論文
2008-02-25