アルツハイマー型痴呆における大脳誘発電位(神経内科学教室竹宮敏子教授退任記念特別号)

概要

論文の詳細を見る
Evoked potentials (EPs) are defined as potentials which are evoked at short latencies (< 100 msec) from the nervous systems specifically related to stimuli given and are classified into visual evoked potentials (VEPs), auditory evoked potentials, somatosensory evoked potentials, and so on, based on modalities of sensory receptors stimulated. Middle-latency evoked responses (MLRs) are also classified as being EPs. Neural pathways and/or neurotransmitters responsible for generation of each EPs have been clarified, and are clinically used for pathophysiological studies and adjunctive diagnoses. The cholinergic visual pathway directly connected to the visual association cortices, not via the visual radiate and the primary visual cortex, is reported to be involved in the generation of P2, a component of flash VEPs. The middle temporal area (V5), the visual association cortex of visual motion perception, is supposed to be involved in the generation of N190, the latest component of motion VEPs. The cholinergic, activating ascending-reticular system from the midbrain to the thalamus in the generation of Pb, a component of MLRs. Among the EPs, P2 of the flash VEPs, N190 of the motion VEPs and Pb of the MLRs are to be clinically applied for clarification of pathophysiology and adjunctive diagnosis of DAT.
東京女子医科大学の論文
2000-12-30