急性期脳梗塞における病型・大きさと危険因子・凝血学的分子マーカーの関係についての検討(神経内科学教室岩田誠教授退任記念特別号)

概要

論文の詳細を見る
Background: Cerebral infarctions are classified into three major clinical categories type: atherothrombotic stroke (ATS), cardioembolic stroke (CES), and lacuna stroke (LAS). We examined the relationship between stroke type and infarction size with risk factors and coagulation-fibrinolysis markers in patients with acute ischemic stroke. Methods: We examined 150 patients with acute ischemic stroke admitted to the Department of Neurology, Tokyo Women's Medical University Hospital. Cerebral infarctions were classified into small infarctions (less than 1.5 cm; S), large infarctions (more than 1/3 of the cerebral hemisphere; L), and medium-sized infarctions (between S and L; M). We compared systolic blood pressure, diastolic blood pressure, hematocrit, total cholesterol, high density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hemoglobin Ale, white blood cell count (WBC), CRP levels, fibrinogen levels, β-thromboglobulin (β-TG) levels, platelet factor 4 (PF4) levels, and thrombin-antithrombin III complex (TAT) levels between types of ischemic stroke and the size of the cerebral infarction. The relationship between the type of stroke and the risk factors was evaluated. Results: There were 32 patients with LAS, 57 with ATS, and 61 with CEA. WBC and CRP were highest in CES patients and lowest in LAS patients. The sizes of the infarcts were S in 77 patients, M in 58, and L in 15. WBC count and fibrinogen were significantly higher in the L group than in the M or S groups. WBC count, β-TG, and PF4 were significantly higher in the M and L groups than in the S group. There were no significant differences in the other variables between the groups. Regardless of the type of stroke, no significant difference was noted in the incidence of any risk factor between the LAS and ATS groups. Conclusions: WBC count and CRP were higher in CES than in ATS or LAS patients, suggesting association with the large size of the infarct. WBC count and fibrinogen were higher in the L group than in the M or S groups, suggesting association with inflammation. β-TG and PF4 levels were higher in the M and L group than in the S group, suggesting a stronger association with platelet activation.
2008-02-25

急性期脳梗塞における病型・大きさと危険因子・凝血学的分子マーカーの関係についての検討(神経内科学教室岩田誠教授退任記念特別号)

スポンサーリンク

概要

著者

関連論文

スポンサーリンク