パーキンソン病の視覚性情報処理能 : 広義の事象関連電位による検討(神経内科学教室竹宮敏子教授退任記念特別号)

概要

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We aimed to clarify the cognitive processes which play a role in visual cognitive dysfunction of Parkinson's disease (PD) using various event-related potentials (ERPs). The ERPs used comprised early negative components, late components and nogo ERPs which are generated in the frontal lobe and reflect the process of the inhibition of motor responses. We also evaluated visual-motion perception using motion-related visual evoked potentials (MVEPs). The incidence of nogo P3 abnormality was higher than that of go P3, nogo P3 was decreased and the nogo P3 was delayed. Nogo P3 and nogo potential in the frontal region were increased. In MVEPs, three components were evoked by the motion stimulus of solid circles. The first positive wave P110 was designated in the occipital region, followed by two negative waves, i.e., N145 in the occipital region and N180 in the occipitotemporal region. Three patients had delayed P110, and one had delayed N145, while N145 and N180 were obscure in two each. The inhibition processes in the motor responses in PD are different from those in normals. Nogo P3 and nogo potential might be useful for evaluating cognitive function in PD without dementia. Some PD patients may have abnormal visual-motion perception as evaluated by MVEPs.
東京女子医科大学の論文
2000-12-30