視神経脊髄炎(NMO)における免疫吸着療法の検討(神経内科学教室岩田誠教授退任記念特別号)

概要

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Neuromyelitis optica (NMO) is an idiopathic inflammatory demyelinating disease of the central nervous system characterized by optic neuritis and myelitis. Recently, anti aquaporin-4 antibody, specifically detected in sera from NMO patients, was discovered. The effectiveness of immunoadsorption plasma pheresis (IAPP) therapy for treating acute exacerbations of NMO has not been well evaluated; thus, accumulation of therapeutic experience for this disease is important. We report 3 patients with acute exacerbations of NMO. These patients were unresponsive to intravenous methylprednisolone therapy but showed significant improvement after IAPP therapy. IAPP therapy was well tolerated and effective for a patient with acute exacerbation during pregnancy. We conclude that IAPP therapy is a therapeutic option for patients with a fulminant attack of NMO. It is relatively safe and applicable for patients with acute exacerbation during pregnancy.
東京女子医科大学の論文
2008-02-25