マイクロ流路内付設型電気センサを用いた赤血球変形能の計測(流体工学,流体機械)

概要

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A sensor which can efficiently and sequentially measure the deformability of a single red blood cell (RBC) flowing in a micro-channel is proposed in the present study. Counter-electrode-type micro membrane sensors are attached onto the channel bottom wall and the time-sequential data of the electric resistance is measured using an alternating current vs. voltage (I-V) method as the RBC passes between the electrodes. The RBC is deformed due to the high shear flow having the degree depending on its elastic modulus, and the profile of the resistance, which is believed to be unique to the shape of the RBC, is analyzed to obtain the deformability of each cell. In the first half of this article, numerical simulation on the electric field around the electrodes and RBC is conducted to evaluate the effects of the RBC height location, channel height, distance between electrodes, electrode width and RBC shape on the sensor sensitivity. In the latter half, experiment is carried out with the samples of normal human RBC and glutaraldehyde-treated (rigidized) RBC to evaluate the feasibility of the present method.
2009-11-25