腎生検について : その病理学的意義

概要

論文の詳細を見る
Needle biopsies have widely been used in the diagnosis and management of renal diseases since Iversen and Brun (1951). For these several years the authors have also performed an increasing number of renal biopsies for medical diseases of the kidney. Techniques, indications, contraindications, complications, and dangers as well as clinical values of these procedures have already been reported and discussed by a number of workers. In this paper some fundamental morphological problems in the renal biopsy and its significance for pathology are discussed, and a few cases studied by serial renal biopsies or a subsequent autopsy are also presented. 1) It is imperative that the small biopsy specimens be quickly placed in good fixative and handled in a shortest time before and during paraffin embedding. 2) Differences of the tissue components in renal biopsies performed in different directions and depth are explained by topographic differences in the architecture of kidneys. 3) In understandig structural alterations of the urinary tubules which are inevitably related to functional changes it is necessary to regard a complex structure consisting both of tubular epithelium, basement membrane, and of interstitium containing blood and lymph capillaries and nerves as the functional unit of urinary tubules. 4) Through serial renal biopsies it is highly promising to establish the dynamic morphology of renal diseases. The accuracy of interpretation can be ascertained by comparing the biopsy findings with autopsy findings obtained subsequently as well as with the clinical and laboratory data. 5) It is one of the most effective ways at the present situation of methodology in comprehending the correlation between structure and function of the kidney to compare the dynamic morphology clarified by serial renal biopsies with dynamic functional changes studied at the wards and laboratories. 6) Some examples of healing, prolongation, and latency of glomerulonephritis ; effect of ACTH and steroid hormone on nephrotic syndrome ; disparity between the effect of insulin and sulfonilurea upon hyperglycemia and the development of diabetic nephropathy ; and the renal failure in the course of chronic essential hypertension are illustrated in the description of cases.
千葉大学の論文
1961-07-28

腎生検について : その病理学的意義

スポンサーリンク

概要

著者

関連論文

スポンサーリンク