悪性胸膜中皮腫の1剖検例

概要

論文の詳細を見る
An autopsy case of malignant mesothelioma probably originated in the left pleura of a 77-year-old man is presented. In this case the spread of the tumor was at first characterized by continuous extension to subserous connective, adipose and muscular tissues of the left parietal pleura, and to interlobar fissures and pulmonary septas of the left lung, and secondly by metastases to bifurcation lymph nodes, right pleura and lung, heart, thyroid, liver, pancreas etc. The tumor had a strong tendency to spread by contiguity and serosal seeding, and most of the metastatic nodules of the right lung, liver etc. were also recognized just beneath the serosa. Microscopically, the tumor had a characteristic cytoarchitecture that was papillomatous or "villous carcinoma"-like appearance in some areas and fibrosarcomatous in others. The tumor cells showed frequently phagocytic activities, i. e., erythro-, siderophagocytosis, anthracosis, hyaline droplet degeneration etc. and sometimes formation of giant cells. At times tumor cells demonstrating central pale areas of the cytoplasm and peripherally arranged nucleus were recognizable, permitting an impression of signet ring cells. Such cells, however, contained no substance tinctorial with mucicarmine or periodic acid-Schiff's stain. It may be worthy of note that the tumor cells had a potency to proliferate in various kinds of environments, that is, in the serous cavity (pleural cavity), in the intramural organ tissues (pulmonary septa and alveolar wall, heart, thyroid, liver, pancreas etc.), in the body fluid (blood and lymph vessels) and on the internal surface of the body (alveolar surface), and the cytoarchitecture of the tumor was, in general, epitheliomatous or carcinomatous in the superficial or central layers and sarcomatous in the deeper or peripheral zone. Such a case may offer an evidence of multipotentiality of mesothelial cells even in their neoplastic transformation.
千葉大学の論文
1958-09-28

悪性胸膜中皮腫の1剖検例

スポンサーリンク

概要

著者

関連論文

スポンサーリンク