ウサギにおける大腸菌による副鼻腔病巣感染の実験病理学的研究

概要

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Experimental morphopathological study of focal infection of paranasal sinuses with Escherichia coli (strain A 34) in 14 rabbits (34 to 362 experimental days) is presented. Among these animals moderate anemia developed in the terminal stage and leukocytosis in the intermediate stage of the course of infection. In the bone marrow, spleen, liver and lymph nodes systemic immune reaction took place, which was especially characterized by mobilization of erythro- and siderophagocytes. Bone marrow demonstrated no remarkable exhaustion state even in the prolonged infection. Adrenals showed a tendency to hypertrophy generally. In addition, so-called allergic-hyperergic disorders such as focal necrosis of liver accompanied by fibrinoid thrombosis of sinusoids (2 cases), carditis of rheumatic type (4 cases), diffuse pneumonitis (12 cases), diffuse glomerulonephritis (5 cases), interstitial myositis (3 cases), synovitis of rheumatic type (1 case) and endarteritis obliterans or panarteritis (9 cases) were also encountered. The experimental results obtained here may offer a fundamental data in discussing the problem of focal infection with Escherichia coli.
千葉大学の論文
1959-01-28