甲状腺中毒症における赤血球炭酸脱水酵素Iアイソザイムおよび亜鉛濃度は2ヶ月前の平均化された甲状腺ホルモン濃度を反映する

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In the present review, the clinical utility of determining red blood cell (RBC) carbonic anhydrase I isozyme (CA1) and zinc (Zn) concentrations in patients with various forms of thyroid disease is discussed. RBC CA1 and Zn concentrations were both decreased in patients with hyperthyroid Graves' disease, and the RBC CA1 concentration significantly (r=0.95) correlated with the RBC Zn concentration. After treatment, the normalization of RBC CA1 and Zn lagged 2 months behind normalization of plasma thyroxine (T4) and triiodothyronine (T3) levels. Furthermore, the highest correlation coefficients were observed between RBC CA1 and Zn levels and plasma thyroid hormone levels measured 8 weeks earlier. Transient thyrotoxicosis due to destructive thyroiditis did not cause significant changes in the RBC CA1 and Zn concentrations. T3 at a physiological free concentration significantly decreased the level of CA1 mRNA and the concentration of CA1 in burst-forming unit-erythroid-derived cells. These results indicate that the measurement of RBC CA1 and Zn concentrations may be useful as follows: (1) in obtaining an accurate estimate of the extent of elevated thyroid hormone levels in hyperthyroid patients in whom serial measurements were not obtained over time; (2) in differentiating patients with hyperthyroid Graves' disease from those with transient thyrotoxicosis.総説Review Article
東北大学の論文