高時間・空間分解能観察に対応する新規な細胞伸展マイクロデバイスの開発(機械力学,計測,自動制御)

概要

論文の詳細を見る
In this study, we have developed a novel cell stretching micro device to observe cellular response to mechanical stimuli with high spatial and temporal resolution. In conventional cell stretching device, rigid displacement of cell body during stretching operation is not negligible. And this rigid displacement makes it difficult to observe instant initial cellular response to stretching. The novel micro device is fabricated by applying MEMS technique, and consists of a transparent elastic micro chamber and a micro linkage mechanism. The micro chamber and linkage mechanism is fabricated by micro molding and multiple exposure technique of photoresist, respectively. We demonstrated availability of fabrication process, and evaluated performance of the micro device. When applying a stretch to chamber, rigid displacement was well suppressed. This result indicated a potential of this device to observe instant initial cellular response to stretching mechanical stimuli.
社団法人日本機械学会の論文
2008-10-25