J0204-1-4 光を用いた関節軟骨の定量評価方法の開発と検討([J0204-1]バイオトライボロジー(1))

概要

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Osteoarthritis of the knee is deeply related to the degeneration of articular cartilage. In this study, the evaluation method for the degeneration by use of light scattering and absorption characteristic of articular cartilage was proposed. As light sources, three LED with wavelengths of 365nm, 540nm and 630nm were used. The specimen harvested from porcine knee joint, were digested by collagenase and hyaluronidase to degenerated artificially. At three light sources, there was significant difference between intact and degenerated specimen of collagenase group. This suggests that the optical characteristic mainly depends on the collagen fibril of articular cartilage. The sensitivity of optical measurements is low compared with that of ultrasound. Since optical path runs though deep layer of articular cartilage, it suggests that., this evaluation can investigate the inner properties of articular cartilage.
一般社団法人日本機械学会の論文
2010-09-04