サイクラミン酸ナトリウム(チクロ)の大腸菌(Escherichia Coli K-12)に対する影響及びその作用機作に関する研究(第一報)

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The investigation was carried out for the purpose of studying the influence of sodium cyclamate (CHS-Na) on Escherichia coli K-12 at the enzymatic level and its mechanism. The present paper dealt with the experiment of growth curve, microscopic observation, oxidation of glucose and some acids of TCA-cycle, and biosynthesis of β-galactosidase. Growth inhibition by CHS-Na appeared at higher concentration than 3% of CHS-Na and complete at 4%. The E. coli forms at two hours after the addition of CHS-Na were smaller than the start and at five hours after the start, the medium containing CHS-Na became sticky. Inhibitory effect of CHS-Na on oxygen uptake of glucose, citrate, α-ketoglutarate and succinate was indicated but oxygen uptake of pyruvate was not inhibited by CHS-Na. The biosynthesis of β-galactosidase was not inhibited by CHS-Na.
東京家政学院大学の論文