Effects of Dose of Recombinant Human BMP-2 on Bone Formation at Palatal Sites in Young and Old Rats
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概要
- 論文の詳細を見る
This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS). New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0μg to 4μg, and decreased significantly as the dosage increased from 8μg to 24μg. In contrast, in the 70w rats, TNB increased as the dosage increase from 0μg to 16μg, and did not significantly change as the dosage increased from 16μg to 24μg. These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.
- 日本歯科理工学会の論文
著者
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MATSUMOTO Atsushi
Department of Pediatrics, Jichi Medical School
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NISHITANI Yoshihiro
Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pha
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YOSHIYAMA Masahiro
Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pha
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Yamaji Kozo
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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Yoshiyama Masahiro
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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Yoshiyama Masahiro
Department Of Conservative Dentistry Tokushima University School Of Dentistry
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Nishitani Yoshihiro
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Nishitani Yoshihiro
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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KAWANAMI Masamitsu
Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University
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ODAJIMA Tomoomi
Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University
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IWASAKA Kensuke
Department of Restorative and Biomaterials Sciences, Division of Operative Dentistry, Meikai Univers
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YOSHIMITSU Keiko
Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okay
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Yamamoto Kazuyo
Osaka Dental Univ. Osaka Jpn
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Odajima Tomoomi
Department Of Periodontology And Endodontology Division Of Oral Health Science Hokkaido University G
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Yoshiyama Masahiro
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Kawanami Masamitsu
Department Of Periodontology And Endodontology Division Of Oral Health Science Hokkaido University G
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Kawanami Masamitsu
Department Of Periodontology And Endodontology Division Of Oral Health Science Hokkaido University G
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Yoshimitsu Keiko
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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Yoshiyama Masahiro
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Iwasaka Kensuke
Department Of Restorative And Biomaterials Sciences Division Of Operative Dentistry Meikai Universit
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Matsumoto Atsushi
Department Of Electric Engineering Hiroshima Institute Of Technology
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Yasuno Kenzo
Graduate School Of Dentistry (operative Dentistry) Osaka Dental University
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