Dentin Regeneration by Direct Pulp Capping using rhBMP-2
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概要
- 論文の詳細を見る
The purpose of this study was to evaluate the effect of direct pulp capping using recombinant human BMP-2 (rhBMP-2) on dentin regeneration. RhBMP-2 (1.0 μg/μl) was dissolved in alginate-based gel (AG). Cavities with the exposed pulp area were prepared of first molars in Wister rats. All cavities were divided into two groups: The exposed pulps were covered with AG contained rhBMP-2 (BMP group), and covered with AG alone (AG group). Then they were sealed with glass ionomer cement (Fuji IILC EM). The animals were sacrificed at 3 and 8 weeks after operation. In both groups, the covered materials were observed at 3 weeks after operation, while they had disappeared and the tertiary dentin formation was observed into the prepared cavity at 8 weeks after operation. Thickness of the tertiary dentin of BMP group was significantly higher than that of AG group (P<0.05). These results suggest that AG is effective scaffold and direct pulp capping using AG contains rhBMP-2 is capable of enhancing dentin regeneration.
- 日本再生歯科医学会の論文
- 2008-03-30
著者
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NISHITANI Yoshihiro
Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pha
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YOSHIYAMA Masahiro
Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pha
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Yamaji Kozo
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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Izawa Shunji
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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Yoshiyama Masahiro
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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Yoshiyama Masahiro
Department Of Conservative Dentistry Tokushima University School Of Dentistry
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Nishitani Yoshihiro
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Nishitani Yoshihiro
Department Of Operative Dentistry Field Of Study Of Biofunctional Recovery And Reconstruction Okayam
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HORIKAWA Gen
Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okay
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Horikawa Gen
Department Of Periodontology And Endodontology Division Of Oral Health Science Hokkaido University G
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Yamamoto Kazuyo
Osaka Dental Univ. Osaka Jpn
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Yoshiyama Masahiro
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Yoshiyama Masahiro
Department Of Operative Dentistry Okayama University Graduate School Of Medicine Dentistry And Pharm
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Yasuno Kenzo
Graduate School Of Dentistry (operative Dentistry) Osaka Dental University
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