Biopharmaceutical Studies of Thiazide Diuretics. III. : In Vivo Formation of 2-Amino-4-chloro-m-benzenedisulfonamide as a Metabolite of Hydrochlorothiazide in a Patient(Pharmaceutical)
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概要
- 論文の詳細を見る
Urine, plasma and erythrocytes from a patient receiving hydrochlorothiazide were examined by high-performance liquid chromatography. The urine and erythrocyte showed an unknown peak in the chromatograms. This substance was identified as 2-amino-4-chloro-m-benzenedisulfonamide and the identification was confirmed by comparison of the substance with an authentic sample obtained by synthesis. All data were analyzed with a PC 9801VM computer in conjunction with a JASCO MULTI-320 multi-wavelength ultraviolet detector.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
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ORITA YOSHIMASA
First Department of Medicine, Osaka University Medical School
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OKUDA Teruaki
Pharmaceutical Research Division, Takeda Chemical Industries, Ltd.
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Okuda T
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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Okuda Teruaki
Faculty Of Pharmaceutical Sciences Osaka University
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Orita Y
First Department Of Internal Medicine:osaka University Hospital
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Nakahama Hajime
First Department Of Internal Medicine Hyogo College Of Medicine
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ITOH SOICHI
Faculty of Pharmaceutical Sciences, Osaka University
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YAMAZAKI MASARU
Faculty of Pharmaceutical Sciences, Osaka University
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FUKUHARA YOSHIFUMI
First Department of Internal Medicine, Osaka university Medical School
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Orita Yoshimasa
The First Department Of Medicine Osaka University Medical School
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Yamazaki Masaru
Faculty Of Pharmaceutical Science Osaka University
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Orita Yoshimasa
First Department of Internal Medicine:Osaka University Hospital
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