A Quantum Chemical Study with Special Reference to the Sulfamyl Group of Sulfonylureas
スポンサーリンク
概要
- 論文の詳細を見る
HUCKEL's LCAO-MO Method was applied to the sulfamyl part of sulfonylureas and related compounds. The parameters used were already discussed in the authors' previous report. |K| values of the lowest vacant energy level of sulfonylureas were less than those of DPN. Such characteristic nature of the compounds seems to unrelated to their hypoglycemic activity. Hypoglycemic activity, seems to depend on the structural specificity of the nucleophilic reaction site of oxygen symmetrically and the electrophilic reaction site of the sulfur in the sulfamyl part between banzene and the urea portion. Moreover, a specific electronic environment required for the urea portion of sulfonylureas was pointed out as essential nature. A continuous π-electron bonded structure from benzene to the sulfamyl part and to the urea portion seems to be indispensable in enhancing water permeability of the toad bladder. The quantum chemical significance of R and R' portion was discussed.
- 社団法人日本循環器学会の論文
- 1970-11-20
著者
-
Takamitsu Yoshihiro
Department Of Medicine Kagawa Medical School
-
ABE HIROSHI
The First Department of Medicine, Osaka University School of Medicine
-
Yamabe Takashi
National Cardiovascular Center
-
ORITA YOSHIMASA
The First Department of Medicine, Osaka University, Medicine School
-
ANDO AKIO
The First Department of Medicine, Osaka University, Medicine School
-
TAKAMITSU YOSHIHIOR
The First Department of Medicine, Osaka University, Medicine School
-
URAKABE SHIGEHARU
The First Department of Medicine, Osaka University, Medicine School
-
SHIRAI DAIROKU
The First Department of Medicine, Osaka University, Medicine School
-
Ando Akio
The First Department Of Internal Medicine Osaka University Osaka
-
Urakabe Shigeharu
First Department Of Medicine Osaka University Medical School
-
Shirai Dairoku
The 1st Department Of Internal Medicine Osaka University Medical School
-
Shirai Dairoku
Ist Div. Dept. Of Med. (prof. T. Yoshida) Osaka Univ. Hosp. Osaka University Med. School Osaka
-
Urakabe Shigeharu
The First Department Of Medicine Osaka University Medical School
-
Orita Yoshimasa
Department Of Medicine Osaka University Medical School
-
Orita Y
First Department Of Internal Medicine:osaka University Hospital
-
Takamitsu Yoshihiro
The First Department Of Medicine Osaka University Medical School
-
Ando Akio
The First Department Of Medicine Osaka University Medical School
-
Orita Yoshimasa
The First Department Of Medicine Osaka University Medical School
-
Abe Hiroshi
The First Department Of Internal Medicine Osaka University Medical School
関連論文
- ROLE OF MESANGIAL PROLIFERATION IN ANGIOTENSIN II AND ANTIDIURETIC HORMONE INDUCED CHANGES IN GLOMERULAR FILTRATION RATE
- Altered Loading Sequence as an Underlying Mechanism of Afterload Dependency of Ventricular Relaxation in Hearts In Situ : SYMPOSIUM ON THE INTERACTION BETWEEN THE HEART AND THE VESSELS
- THE FUNCTIONAL CHARACTERISTICS OF CULTURED RAT MESANGIAL CELL
- EFFECT OF A TXA_2 SYNTHETASE INHIBITOR ON CYCLICAL REDUCTIONS OF CORONARY FLOW OF CANINE CORONARY CIRCULATION : POSSIBLE ROLE OF PGH_2 "STEAL" PHENOMENON BETWEEN PLATELET AND VASCULAR TISSUE : Ischemic Heart Disease (II), Coronary Circulation : II : 48 An
- THROMBOXANE A_2 AS AN ENHANCING FACTOR IN CORONARY ARTERIAL SPASM IN VARIANT ANGINA : Ischemic Heart Disease (II), Coronary Circulation : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- DETERMINATION OF PLASMA THROMBOXANE B_2 BY RADIOIMMUNOASSAY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- EFFECT OF PHOSPHOLAMBAN PHOSPHORYLATION ON Ca^-DEPENDENT ATPase OF SOLUBILIZED CARDIAC SARCOPLASMIC RETICULUM : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- PURIFICATION OF PHOSPHOLAMBAN FROM CARDIAC SARCOPLASMIC RETICULUM : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry
- INCREASED THROMBOXANE A_2 GENERATION AND EFFECT OF ITS BLOCKADE IN UNSTABLE ANGINA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Ischemic Heart Disease (II)
- DISORDERS OF PLATELET AND CORONARY ARTERY REACTIVITIES IN PATIENTS WITH CORONARY ATHEROSCLEROSIS : ALTERED METABOLISM OF TXA_2 AND PGI_2 : Ischemic heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- CLINICAL SIGNIFICANCE OF EXCESSIVELY GENERATED THROMBOXANE A_2 DURING THE ACUTE PHASE OF MYOCARDIAL INFARCTION : Ischemic Heart Disease (II), Coronary Circulation : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- ASSESSMENT OF INFARCT SITE AND SIZE IN ACUTE MYOCARDIAL INFARCTION FROM PRECORDIAL ST POTENTIALS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Vectorcardiography Mapping
- BIOMATHEMATICAL ANALYSIS OF BIOLOGICAL SYSTEM : (REPORT 37) A DIGITAL SIMULATION STUDY OF CORONARY CIRCULATION : (Part II)
- SELECTION OF OPTIMAL BALLOON DIAMETER IN PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY (PTMC) USING INOUE BALLOON CATHETER : Valvular Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY : IMMEDIATE AND FOLLOW-UP RESULTS : Echocardiography, Pulsed Doppler : 53 Annual Scientific Meeting, Japanese Circulation Society
- -22-SIGNIFICANCE OF THE 22,000-DALTON PROTEIN PHOSPHOLAMBAN IN cAMP-MEDIATED STIMULATION OF Ca TRANSPORT BY CARDIAC SARCOPLASMIC RETICULUM : Cardiac Metabolism : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 54) Study on Left Ventricular Diastolic Behavior by a Combined Method of Echocardiography and Catheter-tip Manometry : Ventricular Stiffness Constant (K_v) and Myocardial Stiffness Constant (K_m). : 第41回日本循環器学会近畿地方会
- QUANTITATIVE ASSESSMENT OF LEFT VENTRICULAR WALL MOTION BY CINEVENTRICULOGRAPHY : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- THE COMPUTERIZED MYOCARDIAL SCINTIGRAPHY IN THE DIAGNOSIS OF MYOCARDIAL DISEASES WITH ABNORMAL Q WAVES : (Part III)
- Add. DATA PROCESSING FOR DELINEATION OF CARDIAC BORDER OF SCINTIPOTOS WITH A DIGITAL COMPUTER
- Add. TIME RELATIONSHIP AMONG SYSTOLIC HUMP, DOPPLER BLOOD FLOW SIGNAL AND CARDIAC MURMUR IN CASE OF IDIOPATHIC HYPERTROPHIC SUBAORTIC STENOSIS
- CLINICAL USE AND ACTION MECHANISM OF ANTIDIURETICS IN DIABETES INSIPIDUS
- STUDIES ON HUCKEL'S MOLECULAR-ORBITAL CALCULATION (3dπ-2pπ) OF THE SULFAMYL PART OF THIAZIDE DIURETICS
- A BIO-PHYSICAL STUDY OF THE PHARMACOLOGICAL ACTION OF DIURETICS (Report 20) : Effects of diuretics on Na, K-dependent ATPase and K-dependent phosphatase of the rat kidney cortex : Proceedings of the 34th Annual Meeting of the Japanese Circulation Society
- A Quantum Chemical Study with Special Reference to the Sulfamyl Group of Sulfonylureas
- A Quantum Chemical Study extended to the Sulfamyl Group of Thiazide Diuretics
- Effect of Urea Derivatives and Analgesics on the Permeability to Water and Electrical Properties of the Urinary Bladder of the Toad
- Effect of Sulfonylureas on the Permeability to Water and Electrical Properties of the Urinary Bladder of the Toad
- A QUANTUM-BIOLOGICAL STUDY OF THE PHARMACOLOGICAL ACTION OF THIAZIDE DIURETICS (THE 14TH REPORT) : Stability Constant of Metal Chelate Compounds of Thiazide Diuretics and its Significance
- 100. Studies on the Pharmacological Action of Thiazide Diuretics referring to its Metal Chelating Action (6th Report) The Bio-Physical Studies on the Pharmacological Action
- 99. Biometrical Analysis in Clinical Medicine (Report 7) Clinical Trial of Combined Effect of Furterene Formate and Chlorbenzene Sulfonamide
- Studies on the Renal Function Test (Report 57) : Mathematical Analysis of Urea Clearance Test : PROCEEDINGS OF THE 23RD KINKI REGIONAL MEETING
- EFFECTS OF ASYNERGY ON LEFT VENTRICULAR FUNCTION : EXERCISE ECHOCARDIOGRAPHY : Echocardiography : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- HYPOKALEMIA AND METABOLIC ALKALOSIS RESULTING FROM OVERUSE OF MAGNESIUM OXIDE
- PROGNOSIS OF CHRONIC GLOMERULONEPHRITIS IN ADULT PATIENTS ESTIMATED ON THE BASIS OF THE MARKOV PROCESS
- CLINICAL STUDY ON IDIOPATHIC EDEMA, ESPECIALLY SYMPTOMS AND SIGNS : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- STUDIES ON A METAL-CHELATING ACTION OF FUROSEMIDE, ETHACRYNIC ACID AND BUMETANIDE : (Part II)
- THE EFFECT OF SQ 14225 ON THE RESPONSE OF PLASMA ALDOSTERONE TO UPRIGHT POSITION IN PATIENT WITH MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS : Kidney : 46th Annual Scientific Meeting, Japanese Circulation Society
- Transmitral Blood Flow Reflecting Diastolic Behavior of the Left Ventricle in Health and Disease : A Study by Pulsed Doppler Technique : SYMPOSIUM ON HEART MECHANICS IN DIASTOLE
- ANALYSIS OF THE HOMOGENEITY OF LEFT VENTRICULAR WALL MOTION BY SIMULTANEOUS BIPLANE ECHOCARDIOGRAPHY : New Techniques, Echocardiography II : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -190-THREE-DIMENSIONAL ECHOCARDIOGRAPHY AND ITS CLINICAL APPLICATION : 7th Report : Phonocardiogram, Echocardiogram : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ECHOCARDIOGRAPHIC ANALYSIS OF LEFT VENTRICULAR HYPERTROPHY IN HYPERTENSION
- -0192-SIGNIFICANCE OF INTRA-BALLOON PRESSURE MONITORING DURING PERCUTANEOUS TRANSVENOUS MITRAL COMMISSUROTOMY USING THE INOUE BALLOON CATHETER
- A Study on the Mechanism of Transfer of Sulfa Drugs by using Stop Flow Method (II)
- Studies on Renal Tubular Transport Mechanism of Amino Acids Utilizing the Stop Flow Method
- Studies on the Renal Countercurrent System (Report 19) : Effect of Cyclic-AMP on the Renal Papillia Studying by a Retrograde Infusion Experiment in Rabbid : PROCEEDINGS OF THE 23RD KINKI REGIONAL MEETING
- A Quantum-biological Analysis of Thiazide Diuretics and Ethacrynic Acid
- A Quantim-Biological Study of the Pharmacological Action of Thiazide Diuretics : Part III
- Effect of Urinary Urea/Nonurea on Urinary Concentrating Ability and Renal Water Economy in Patients with Renal Diseases
- A Quantum-Biological Study of the Pharmacological Action of Thiazide Diuretics
- Studies on the Transport Mechanism of Sulfonamide Compounds in Renal Tubules : Stopflow Analysis Applied to the Excretion of Sulfonamide Compounds
- Studies on the Transport Mechanism of Aminoacids in the Renal Tubules : Part II Mathematical Evaluation of Urinary Aminoacid Excretion
- Studies on the Transport Mechanism of Aminoacids in the Renal Tubules : Part I Studies on the Mechanism of Aminoaciduria from the Analytical Standpoint of Titration Curve
- Mathematical Analysis of the Effect of GFR Reduction on the Urinary Osmolality in Human and Dog
- Quantum-biological Analysis of the Relation of Urea and its Related Compounds to Water in Renal Medulla
- Effect of Urinary Urea/Nonurea : On Urinary Concentrating Ability and Renal Water Economy in Human Subjects
- 57) Studies on the Aminoacids Transport of Renal Tubules : Report 15 Effect of Urine Flow Rate on the Urinary Excretion of Endogeneous Aminoacids
- Biomathematical Analysis of Renal Function
- Analysis of Urea Excretion with Special Reference to the Influence of Abrupt Change in Urine Flow
- Analysis of Impaired Urinary Concentrating Ability of Phenacetin Fed Rat
- INCREASED DEPENDENCY OF LEFT VENTRICULAR RELAXATION ON SYSTOLIC PRESSURE LOADING IN PATIENTS WITH CORONARY ARTERY DISEASE : Ventricular Function : 46th Annual Scientific Meeting, Japanese Circulation Society
- HIGH PLASMA RENIN ACTIVITY IN PATIENTS WITH TAKAYASU'S ARTERITIS
- CYCLIC AMP REGULATION ON CALCIUM TRANSPORT BY CARDIAC SARCOPLASMIC RETICULUM: PHYSIOLOGICAL SIGNIFICANCE OF THE REGULATORY PROTEIN 'PHOSPHOLAMBAN' : IVth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 147. Study on the Transport Mechanism of Amino Acids in Renal Tubules (VIII)
- Study on the Transfer Mechanism of Acidic and Neutral Amino Acids in the Renal Tubules of Dogs (VI)
- G-VECTOR CHANGES IN EXERCISE TEST IN HEALTHY ADULTS AND PATIENTS WITH ISCHEMIC HEART DISEASE : The Fifth Conference on Vectorcardiography
- NONINVASIVE ASSESSMENT OF IMPAIRED EARLY DIASTOLIC FILLING OF LEFT VENTRICLE IN HYPERTENSIVE PATIENTS USING ULTRASONIC PULSED DOPPLER TECHNIQUE : Electrophysiology : 46th Annual Scientific Meeting, Japanese Circulation Society
- CLINICAL SIGNIFICANCE OF EXERCISE-INDUCED ST CHANGES IN PATIENTS WITH PRIOR MYOCARDIAL INFARCTION : Comparison of electrocardiographic and angiographic findings
- AORTIC TURBULENCE AS A CAUSE OF EJECTION MURMURS : A STUDY WITH COMPUTER-AIDED PULSED DOPPLER TECHNIQUE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Phonocardiography
- A NEW PULSED DOPPLER TECHNIQUE FOR NON-INVASIVE INTRACARDIAC FLOW VECTOR MEASUREMENT : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Echocardiography (I)
- Detection and Visualization of Regurgitant Flow in Valvular Diseases by Pulsed Doppler Technique : SYMPOSIUM ON CURRENT PROBLEMS IN VALVULAR HEART DISEASE
- HEMODYNAMIC AND VOLUME CHARACTERISTICS, AND PERIPHERAL PLASMA RENIN ACTIVITY IN TAKAYASU'S ARTERITIS
- Prognosis of Chronic Glomerulonephritis with Special Reference to Hypertension and Renal Function : Prognosis and Treatment of Renal Hypertension
- 糸球体病変の活動度よりみた腎生検病理組織像の分類
- Binding of Hydrochlorothiazide to Erythrocytes
- Biopharmaceutical Studies of Thiazide Diuretics. III. : In Vivo Formation of 2-Amino-4-chloro-m-benzenedisulfonamide as a Metabolite of Hydrochlorothiazide in a Patient(Pharmaceutical)
- Inverse Solution of ST Vector as a Single Unfixed Location Dipole in Patients with Acute Myocardial Infarction : CLINICAL APPLICATION OF BODY SURFACE MAPPING
- Effect of Glucose and Fat Loading on Lipoprotein Lipase Activity in Plasma and Tissues of Diabetes
- The Ultrasound Cardiogram of the Tricuspid Valve in Healthy Subjects