A Quantum-Biological Study of the Pharmacological Action of Thiazide Diuretics
スポンサーリンク
概要
- 論文の詳細を見る
The metal chelating action of the S=0 part of sulfamyl part was assumed on the basis of studies of the electronic state of the sulfamyl part of thiazide diuretics because of its similarity to the phosp'nate part p of ATP. The diuretic activity and inhibitory effect of thiazide on carbonic anhydrase may be explained as resulting from Mg^++ and Zn^++ chelating. ROBLlN'S model explaining the inhibitory effect of the sulfamyl part on carbonic anhydrase activity did not seem adequate from the viewpoint of quantum-chemistry.
- 社団法人日本循環器学会の論文
- 1967-03-20
著者
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Takamitsu Yoshihiro
Department Of Medicine Kagawa Medical School
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ABE HIROSHI
The First Department of Medicine, Osaka University School of Medicine
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Abe Hiroshi
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Furukawa Toshiyuki
The First Department of Medicine, Osaka University Medical School
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Yamabe Takashi
National Cardiovascular Center
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ORITA YOSHIMASA
The First Department of Medicine, Osaka University, Medicine School
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ANDO AKIO
The First Department of Medicine, Osaka University, Medicine School
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URAKABE SHIGEHARU
The First Department of Medicine, Osaka University, Medicine School
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TAKAMITSU YOSHIHIRO
The First Department of Medicine, Osaka University Medical School
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Ando Akio
The First Department Of Internal Medicine Osaka University Osaka
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Urakabe Shigeharu
First Department Of Medicine Osaka University Medical School
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Urakabe Shigeharu
The First Department Of Medicine Osaka University Medical School
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Takamitsu Yoshihiro
The First Department Of Medicine Osaka University Medical School
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Ando Akio
The First Department Of Medicine Osaka University Medical School
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Orita Yoshimasa
The First Department Of Medicine Osaka University Medical School
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Abe Hiroshi
The First Department Of Internal Medicine Osaka University Medical School
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