Effect of Sulfonylureas on the Permeability to Water and Electrical Properties of the Urinary Bladder of the Toad
スポンサーリンク
概要
- 論文の詳細を見る
Chlorpropamide induced an increase in the permeability to water of the urinary bladder of Bufo vulgaris japonicus only when added to the serosal medium even in the absence of vasopressin and this effect was inhibited by epinephrine, glutathione and 10^<-2>2M calcium. Sulfonylureas (chlorpropamide, tolbutamide, carbutamide and acetohexamide) potentiated the vasopressin induced effect on the osmotic flow of water. In contrast chlorpropamide added to the serosal medium obviously inhibited the effect of exogenous cyclic 3', 5'-AMP on the permeability to water in the presence of epinephrine and also markedly depressed the D.C. conductance of the bladder. One possible explanation for the mode of action of chlorpropamide was presented.
- 社団法人日本循環器学会の論文
- 1970-10-20
著者
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Takamitsu Yoshihiro
Department Of Medicine Kagawa Medical School
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ABE HIROSHI
The First Department of Medicine, Osaka University School of Medicine
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Yamabe Takashi
National Cardiovascular Center
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ORITA YOSHIMASA
The First Department of Medicine, Osaka University, Medicine School
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ANDO AKIO
The First Department of Medicine, Osaka University, Medicine School
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URAKABE SHIGEHARU
The First Department of Medicine, Osaka University, Medicine School
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SHIRAI DAIROKU
The First Department of Medicine, Osaka University, Medicine School
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TAKAMITSU YOSHIHIRO
The First Department of Medicine, Osaka University Medical School
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Ando Akio
The First Department Of Internal Medicine Osaka University Osaka
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Urakabe Shigeharu
First Department Of Medicine Osaka University Medical School
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Shirai Dairoku
The 1st Department Of Internal Medicine Osaka University Medical School
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Shirai Dairoku
Ist Div. Dept. Of Med. (prof. T. Yoshida) Osaka Univ. Hosp. Osaka University Med. School Osaka
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Urakabe Shigeharu
The First Department Of Medicine Osaka University Medical School
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Orita Yoshimasa
Department Of Medicine Osaka University Medical School
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Orita Y
First Department Of Internal Medicine:osaka University Hospital
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Takamitsu Yoshihiro
The First Department Of Medicine Osaka University Medical School
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Ando Akio
The First Department Of Medicine Osaka University Medical School
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Orita Yoshimasa
The First Department Of Medicine Osaka University Medical School
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Abe Hiroshi
The First Department Of Internal Medicine Osaka University Medical School
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