Studies on the Transport Mechanism of Aminoacids in the Renal Tubules : Part II Mathematical Evaluation of Urinary Aminoacid Excretion
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概要
- 論文の詳細を見る
1) An introduction was made of a theoretical model in consideration of several factors involved in the structural specificity of nephron. A stoichiometric analysis of aminoacid transfer mechanism in tubular cells was tried by a mathematical treatment. Urinary amino-acid excretion was formulated as follows : ln <CAA>/<GFR>=A- B/V 2) appropriateness of an equation induced by a theoretical model was tested by observing changes of urinary aminoacid excretion due to changes of a minute urine volume and proven to be valid. The normal kidneys of dogs and human beings were put on mannitol and water diuresis and urinary aminoacid excretion rate was measured. Changes of urinary aminoacid may be expressed as In <CAA>/<GFR>-=ln a - B/V with a high statistical reliance. 3) A deformed histidine titration curve suggesting a decrease of equilibrium constant k of transfer reaction in the diseased kidney proved to be the same as that of the normal kidney following correction of some factors on the basis of the theoretical formula. Reduction in reabsorption ratio and reaction constant resulted from an increased urine volume per nephron. 4) In the aminoaciduria in a narrow sense e. g. Fanconi syndrome, evaluation of changes only in the active transfer system becomes possible by correcting other factors by inducing such a theoretical formula. It is believed that this formula can be used as the basis of in-vivo stoichiometric treatment of the transfer mechanism.
- 社団法人日本循環器学会の論文
- 1967-03-20
著者
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ABE HIROSHI
The First Department of Medicine, Osaka University School of Medicine
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Sugii Michio
Cardiac Intensive Care Unit of Osaka Police Hospital
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Abe Hiroshi
Department Of Internal Medicine And Therapeutics Osaka University Graduate School Of Medicine
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Furukawa Toshiyuki
The First Department of Medicine, Osaka University Medical School
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Sugita Minoru
1st Div. Dept. Of Intern. Med. Osaka Univ. Medical School
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Sugita Minoru
The Fifth Department Of Internal Medicine Hyogo College Of Medicine
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SUGITA KO
The First Department of Internal Medicine, Osaka University Hospital Osaka University Medical School
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SUGITA KOU
1st Div., Dept. of Intern. Med., Osaka Univ., Medical School
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Sugita Kou
1st Div. Dept. Of Intern. Med. Osaka Univ. Medical School
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Sugita Minoru
The First Department Of Internal Medicine Osaka University Hospital Osaka University Medical School
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Abe Hiroshi
The First Department Of Internal Medicine Osaka University Medical School
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